TYOBP_HUMAN » TYRO protein tyrosine kinase-binding protein

TYOBP_HUMAN » TYRO protein tyrosine kinase-binding protein
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Topology in Plasma membrane
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TYOBP_HUMAN » TYRO protein tyrosine kinase-binding protein » DNAX-activation protein 12;Killer-activating receptor-associated protein;KAR-associated protein;
Hydrophobic Thickness 34.8 ± 1.4 Å
Tilt Angle 1 ± 3°
ΔGtransfer -40.6 kcal/mol
ΔGfold -12.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 40-65 (40-67)
Pathways

Cell-Cell communication (Reactome)

Developmental Biology (Reactome)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Osteoclast differentiation (KEGG)

PDB 2l34 (A/B=35-67), 2l35 (A=35-67, B=35-66)
OPM 2l34, 2l35, 4wo1, 4wol
Complexes

TYOBP:NKG2C_HUMAN

TYOBP:TYOBP_HUMAN

Interactions

CLC5A, Complex: CLC5A:TYOBP, PubMed

CLM2, Complex: CLM2:TYOBP, PubMed

CLM7, Complex: CLM7:TYOBP, PubMed

KI2S2, Complex: TYOBP:KI2S2, PubMed

KI2S3, Complex: KI2S3:TYOBP, PubMed

KI3S1, Complex: KI3S1:TYOBP, PubMed

KLRD1, Complex: KLRD1:TYOBP:NKG2C, PubMed

NCTR2, Complex: TYOBP:NCTR2, PubMed

NKG2C, Complex: NKG2C:TYOBP, PDBID: 2l35, PubMed

NKG2D, Complex: NKG2D:TYOBP, PubMed

NKG2E, Complex: TYOBP:NKG2E, PubMed

NKG2F, Complex: NKG2F:TYOBP, PubMed

SIG14, Complex: TYOBP:SIG14, PubMed

SIGL5, Complex: SIGL5:TYOBP, PubMed

SIRB1, Complex: SIRB1:TYOBP, PubMed

TREM1, Complex: TYOBP:TREM1, PubMed

TREM2, Complex: TREM2:TYOBP, PubMed

TYOBP, Complex: Transmembrane homodimer of TYOBP, PDBID: 2L34

Domains none
UniProt annotation for TYOBP_HUMAN » TYRO protein tyrosine kinase-binding protein
FUNCTION: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

SUBUNIT: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14. Interacts with CD300LB and CD300E. Interacts with CD300D (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with KLRC2 and KIR2DS3.

TISSUE SPECIFICITY: Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.

DISEASE: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) OMIM: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for TYOBP_HUMAN » TYRO protein tyrosine kinase-binding protein
SIGNAL 1 21 Potential.
CHAIN 22 113 TYRO protein tyrosine kinase-binding protein.
DOMAIN 80 108 ITAM.
SITE 54 54 Important for interaction with transmembrane receptors.
DISULFID 35 35 Interchain.
Amino Acid Sequence for TYOBP_HUMAN » TYRO protein tyrosine kinase-binding protein
MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK