|TXD11_HUMAN » Thioredoxin domain-containing protein 11 » EF-hand-binding protein 1;|
|Hydrophobic Thickness||29.6 ± 2.2 Å|
|Tilt Angle||31 ± 4°|
|Links to TXD11_HUMAN||UniProtKB, Pfam, iHOP, STRING, PharmGKB, HGNC, Wikipedia, Interpro|
|Annotation for TXD11_HUMAN » Thioredoxin domain-containing protein 11|
FUNCTION: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation. |
SUBUNIT: Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widely expressed at low level. Expressed at higher level in thyroid and prostate.
-- Uniprot annotation--
|Comments on TXD11_HUMAN » Thioredoxin domain-containing protein 11|
CHAIN 1 985 Thioredoxin domain-containing protein 11. |
DOMAIN 92 214 Thioredoxin 1.
DOMAIN 649 799 Thioredoxin 2.
COILED 821 919 Potential.
DISULFID 469 472 Redox-active (By similarity).
DISULFID 719 722 Redox-active (By similarity).