TXD11_HUMAN » Thioredoxin domain-containing protein 11
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Topology in Endoplasmic reticulum membrane
Download Coordinates
Topology in Endoplasmic reticulum membrane
 | lumenal side |
| cytoplasmic side |
- Type: 1. Transmembrane bitopic proteins (15 classes)
- Class: 1.13. Enzymes, isomerases (EC 5.) (4 superfamilies)
- Superfamily: 1.13.01. Protein disulfide isomerase (1 family) PF00085 (Pfam)
- Family: 1.13.01.01. Protein disulfide isomerase (6 proteins) IPR013766 (InterPro)
- Species: Homo sapiens (2303 proteins)
- Localization: Endoplasmic reticulum membrane (209 proteins)
| TXD11_HUMAN » Thioredoxin domain-containing protein 11 » EF-hand-binding protein 1; | |
|---|---|
| Hydrophobic Thickness | 29.6 ± 2.2 Å |
| Tilt Angle | 31 ± 4° |
| ΔGtransfer | -10.7 kcal/mol |
| Links to TXD11_HUMAN | UniProtKB, Pfam, iHOP, STRING, PharmGKB, HGNC, Wikipedia, Interpro |
| Topology | Out |
| Domains | AA: 111-212, PDBID: 3boa, Subunit A, Seq Identity:26%, Thioredoxin AA: 691-784, PDBID: 3ed3, Subunit A, Seq Identity:35%, Thioredoxin |
| Transmembrane segments |
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| Segments: 63-87 |
| Annotation for TXD11_HUMAN » Thioredoxin domain-containing protein 11 |
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FUNCTION: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation. SUBUNIT: Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Widely expressed at low level. Expressed at higher level in thyroid and prostate. -- Uniprot annotation-- |
| Comments on TXD11_HUMAN » Thioredoxin domain-containing protein 11 |
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CHAIN 1 985 Thioredoxin domain-containing protein 11. DOMAIN 92 214 Thioredoxin 1. DOMAIN 649 799 Thioredoxin 2. COILED 821 919 Potential. DISULFID 469 472 Redox-active (By similarity). DISULFID 719 722 Redox-active (By similarity). |
