TUTLA_HUMAN » Protein turtle homolog A

TUTLA_HUMAN » Protein turtle homolog A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TUTLA_HUMAN » Protein turtle homolog A » Immunoglobulin superfamily member 9A;IgSF9A;
Hydrophobic Thickness 34.4 ± 3.4 Å
Tilt Angle 22 ± 5°
ΔGtransfer -19.0 kcal/mol
ΔGfold -13.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 735-760 (734-767)
Pathways none
PDB 1v5j (624-718)
OPM none
Complexes none
Interactions none
Domains

AA: 136-223, PDBID: 2V9Q, Subunit A, Seq Identity:34%, Immunoglobulin I-set domain

AA: 226-305, PDBID: 3K0W, Subunit A, Seq Identity:32%, Immunoglobulin domain

AA: 417-490, PDBID: 1CS6, Subunit A, Seq Identity:31%, Immunoglobulin domain

AA: 509-596, PDBID: 1UEN, Subunit A, Seq Identity:29%, Fibronectin type III domain

AA: 625-708, PDBID: 1V5J, Subunit A, Seq Identity:100%, Fibronectin type III domain

UniProt annotation for TUTLA_HUMAN » Protein turtle homolog A
FUNCTION: Functions in dendrite outgrowth and synapse maturation.

SUBUNIT: Interacts with MAGI2 and SHANK1.

DEVELOPMENTAL STAGE: Expressed in a wide variety of tissues at 8 and 14 weeks of gestation.

DOMAIN: The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.

UniProt features for TUTLA_HUMAN » Protein turtle homolog A
SIGNAL 1 20 Potential.
CHAIN 21 1179 Protein turtle homolog A.
DOMAIN 24 124 Ig-like 1.
DOMAIN 136 216 Ig-like 2.
DOMAIN 226 318 Ig-like 3.
DOMAIN 322 410 Ig-like 4.
DOMAIN 418 502 Ig-like 5.
DOMAIN 508 604 Fibronectin type-III 1.
DOMAIN 623 714 Fibronectin type-III 2.
MOTIF 1177 1179 PDZ-binding (By similarity).
DISULFID 41 108 By similarity.
DISULFID 158 206 By similarity.
DISULFID 248 301 By similarity.
DISULFID 344 395 By similarity.
DISULFID 440 486 By similarity.
Amino Acid Sequence for TUTLA_HUMAN » Protein turtle homolog A
MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP PLHVIEWLRF GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV EDQGWYECRV FFLDQHIPED DFANGSWVHL TVNSPPQFQE TPPAVLEVQE LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG QGQVQVQNGT LRIRRVERGS SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA SQDVSLACHA EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP PLLFVSWTKD GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS LGTAGPSPVT RVLLKAPPAF IERPKEEYFQ EVGRELLIPC SAQGDPPPVV SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA HGHWECSASN AVARVATSTN VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS VWYTPLAKRP DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP KRLDGYVLEG RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA GSFVSDPSNT ANVSTSGLEV YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV LVSILAGCLL NRRRAARRRR KRLRQDPPLI FSPTGKSAAP SALGSGSPDS VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL PLEPICRGPD GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA APPDYMDTRR CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA DWTLRERLLP GLLPAAPRGS LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP APGDTSSWAS GPERWPRREH VVTVSKRRNT SVDENYEWDS EFPGDMELLE TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA RCAALREEFL AFRRRRDATR ARLPAYRQPV PHPEQATLL