TRML2_HUMAN » Trem-like transcript 2 protein

TRML2_HUMAN » Trem-like transcript 2 protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TRML2_HUMAN » Trem-like transcript 2 protein » TLT-2; Triggering receptor expressed on myeloid cells-like protein 2;
Hydrophobic Thickness 32.8 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.5 kcal/mol
ΔGfold -23.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 266-290 (264-292)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 16-124, PDBID: 1q8m, Subunit D, Seq Identity:32%, Immunoglobulin V-set domain

UniProt annotation for TRML2_HUMAN » Trem-like transcript 2 protein
FUNCTION: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

SUBUNIT: Interacts with CD276 and this interaction enhances T-cell activation.

TISSUE SPECIFICITY: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.

INDUCTION: Induced in CD4 T-cells by concanavalin-A.

UniProt features for TRML2_HUMAN » Trem-like transcript 2 protein
SIGNAL 1 18 Potential.
CHAIN 19 321 Trem-like transcript 2 protein.
DOMAIN 20 121 Ig-like V-type.
DISULFID 41 105 By similarity.
DISULFID 56 63 By similarity.
Amino Acid Sequence for TRML2_HUMAN » Trem-like transcript 2 protein
MAPAFLLLLL LWPQGCVSGP SADSVYTKVR LLEGETLSVQ CSYKGYKNRV EGKVWCKIRK KKCEPGFARV WVKGPRYLLQ DDAQAKVVNI TMVALKLQDS GRYWCMRNTS GILYPLMGFQ LDVSPAPQTE RNIPFTHLDN ILKSGTVTTG QAPTSGPDAP FTTGVMVFTP GLITLPRLLA STRPASKTGY SFTATSTTSQ GPRRTMGSQT VTASPSNARD SSAGPESIST KSGDLSTRSP TTGLCLTSRS LLNRLPSMPS IRHQDVYSTV LGVVLTLLVL MLIMVYGFWK KRHMASYSMC SDPSTRDPPG RPEPYVEVYL I