TRML1_HUMAN » Trem-like transcript 1 protein

TRML1_HUMAN » Trem-like transcript 1 protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TRML1_HUMAN » Trem-like transcript 1 protein » TLT-1; Triggering receptor expressed on myeloid cells-like protein 1;
Hydrophobic Thickness 37.6 ± 3.4 Å
Tilt Angle 30 ± 0°
ΔGtransfer -30.8 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 161-188 (161-188)
Pathways none
PDB 2frg (20-125)
OPM none
Complexes none
Interactions none
Domains

AA: 17-122, PDBID: 2frg, Subunit P, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for TRML1_HUMAN » Trem-like transcript 1 protein
FUNCTION: Cell surface receptor that may play a role in the innate and adaptive immune response.

SUBUNIT: When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.

TISSUE SPECIFICITY: Detected in platelets, monocytic leukemia and in T-cell leukemia.

UniProt features for TRML1_HUMAN » Trem-like transcript 1 protein
SIGNAL 1 15 Potential.
CHAIN 16 311 Trem-like transcript 1 protein.
DOMAIN 16 121 Ig-like V-type.
MOTIF 279 285 ITIM.
DISULFID 38 104
DISULFID 52 59
Amino Acid Sequence for TRML1_HUMAN » Trem-like transcript 1 protein
MGLTLLLLLL LGLEGQGIVG SLPEVLQAPV GSSILVQCHY RLQDVKAQKV WCRFLPEGCQ PLVSSAVDRR APAGRRTFLT DLGGGLLQVE MVTLQEEDAG EYGCMVDGAR GPQILHRVSL NILPPEEEEE THKIGSLAEN AFSDPAGSAN PLEPSQDEKS IPLIWGAVLL VGLLVAAVVL FAVMAKRKQG NRLGVCGRFL SSRVSGMNPS SVVHHVSDSG PAAELPLDVP HIRLDSPPSF DNTTYTSLPL DSPSGKPSLP APSSLPPLPP KVLVCSKPVT YATVIFPGGN KGGGTSCGPA QNPPNNQTPS S