TRIL_HUMAN » TLR4 interactor with leucine rich repeats

TRIL_HUMAN » TLR4 interactor with leucine rich repeats
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TRIL_HUMAN » TLR4 interactor with leucine rich repeats » Leucine-rich repeat-containing protein KIAA0644;
Hydrophobic Thickness 34.4 ± 5.0 Å
Tilt Angle 30 ± 0°
ΔGtransfer -26.6 kcal/mol
ΔGfold -25.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 693-718 (693-729)
Pathways none
PDB none
OPM none
Complexes none
Interactions

TLR3, Complex: TRIL:TLR3, PubMed

Domains

AA: 62-119, PDBID: 1XCD, Subunit A, Seq Identity:45%, Leucine rich repeat

AA: 83-143, PDBID: 1OZN, Subunit A, Seq Identity:46%, Leucine rich repeat

AA: 107-167, PDBID: 1OZN, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 229-289, PDBID: 2WFH, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 301-360, PDBID: 4P8S, Subunit A, Seq Identity:46%, Leucine rich repeat

AA: 387-415, PDBID: 3REZ, Subunit D, Seq Identity:33%, Leucine rich repeat C-terminal domain

UniProt annotation for TRIL_HUMAN » TLR4 interactor with leucine rich repeats
FUNCTION: Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.

SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation. Interacts with LPS.

TISSUE SPECIFICITY: Highly expressed in the brain, ovary, small intestine and spleen.

INDUCTION: By bacterial lipopolysaccharides (LPS).

UniProt features for TRIL_HUMAN » TLR4 interactor with leucine rich repeats
SIGNAL 1 25 Potential.
CHAIN 26 811 TLR4 interactor with leucine rich repeats.
DOMAIN 26 57 LRRNT.
REPEAT 61 81 LRR 1.
REPEAT 84 105 LRR 2.
REPEAT 108 129 LRR 3.
REPEAT 132 153 LRR 4.
REPEAT 156 177 LRR 5.
REPEAT 180 201 LRR 6.
REPEAT 204 223 LRR 7.
REPEAT 230 251 LRR 8.
REPEAT 254 275 LRR 9.
REPEAT 278 299 LRR 10.
REPEAT 302 323 LRR 11.
REPEAT 326 347 LRR 12.
DOMAIN 359 416 LRRCT.
Amino Acid Sequence for TRIL_HUMAN » TLR4 interactor with leucine rich repeats
MEAARALRLL LVVCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRVVP KTSSLPSPHD VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP KTFEKLSRLE ELYLGNNLLQ ALAPGTLAPL RKLRILYANG NEISRLSRGS FEGLESLVKL RLDGNALGAL PDAVFAPLGN LLYLHLESNR IRFLGKNAFA QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANS LQHLGPRIFQ HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA LYRLDLDGNG WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY LDYLDDQQLQ NGSCADPSPS ASLTADRRRQ PLPTAAGEEM TPPAGLAEEL PPQPQLQQQG RFLAGVAWDG AARELVGNRS ALRLSRRGPG LQQPSPSVAA AAGPAPQSLD LHKKPQRGRP TRADPALAEP TPTASPGSAP SPAGDPWQRA TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ESSDSATLRE LRGDTPYLVC VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL ALLTVNALLV LLALAAWASR WLRRKLRARR KGGAPVHVRH MYSTRRPLRS MGTGVSADFS GFQSHRPRTT VCALSEADLI EFPCDRFMDS AGGGAGGSLR REDRLLQRFA D