TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2

TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2 » TREM-2; Triggering receptor expressed on monocytes 2;
Hydrophobic Thickness 33.2 ± 2.4 Å
Tilt Angle 32 ± 3°
ΔGtransfer -22.8 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 172-196 (172-202)
Pathways

Developmental Biology (Reactome)

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB none
OPM none
Complexes none
Interactions

TYOBP, Complex: TREM2:TYOBP, PubMed

Domains

AA: 19-129, PDBID: 1U9K, Subunit B, Seq Identity:28%, Immunoglobulin V-set domain

UniProt annotation for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2
FUNCTION: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

SUBUNIT: Interacts with TYROBP/DAP12.

TISSUE SPECIFICITY: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.

DISEASE: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) OMIM: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. by mutations affecting the gene represented in this entry.

UniProt features for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2
SIGNAL 1 18 Potential.
CHAIN 19 230 Triggering receptor expressed on myeloid cells 2.
DOMAIN 29 112 Ig-like V-type.
DISULFID 36 110 Potential.
DISULFID 51 60 Potential.
Amino Acid Sequence for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2
MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT