|TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2 » TREM-2; Triggering receptor expressed on monocytes 2;|
|Hydrophobic Thickness||33.2 ± 2.4 Å|
|Tilt Angle||32 ± 3°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||172-196 (172-202)|
Developmental Biology (Reactome)
Immune System (Reactome)
Osteoclast differentiation (KEGG)
|UniProt annotation for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2|
|FUNCTION: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. SUBUNIT: Interacts with TYROBP/DAP12. TISSUE SPECIFICITY: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. DISEASE: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) OMIM: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. by mutations affecting the gene represented in this entry.|
|UniProt features for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2|
SIGNAL 1 18 Potential. |
CHAIN 19 230 Triggering receptor expressed on myeloid cells 2.
DOMAIN 29 112 Ig-like V-type.
DISULFID 36 110 Potential.
DISULFID 51 60 Potential.
|Amino Acid Sequence for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2|
|MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT|