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cytoplasmic side |
TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2 » TREM-2; Triggering receptor expressed on monocytes 2; | |
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Hydrophobic Thickness | 33.2 ± 2.4 Å |
Tilt Angle | 32 ± 3° |
ΔGtransfer | -22.8 kcal/mol |
ΔGfold | -21.0 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC |
Topology | Out |
TM Segments | 172-196 (172-202) |
Pathways | Developmental Biology (Reactome) Immune System (Reactome) Osteoclast differentiation (KEGG) |
PDB | none |
OPM | none |
Complexes | none |
Interactions | |
Domains | AA: 19-129, PDBID: 1U9K, Subunit B, Seq Identity:28%, Immunoglobulin V-set domain |
UniProt annotation for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2 |
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FUNCTION: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. SUBUNIT: Interacts with TYROBP/DAP12. TISSUE SPECIFICITY: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. DISEASE: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) OMIM: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. by mutations affecting the gene represented in this entry. |
UniProt features for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2 |
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SIGNAL 1 18 Potential. CHAIN 19 230 Triggering receptor expressed on myeloid cells 2. DOMAIN 29 112 Ig-like V-type. DISULFID 36 110 Potential. DISULFID 51 60 Potential. |
Amino Acid Sequence for TREM2_HUMAN » Triggering receptor expressed on myeloid cells 2 |
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MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT |