TREM1_HUMAN » Triggering receptor expressed on myeloid cells 1

TREM1_HUMAN » Triggering receptor expressed on myeloid cells 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TREM1_HUMAN » Triggering receptor expressed on myeloid cells 1 » TREM-1; Triggering receptor expressed on monocytes 1;
Hydrophobic Thickness 40.8 ± 2.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -41.1 kcal/mol
ΔGfold -10.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 202-227 (202-232)
Pathways

Hemostasis (Reactome)

Immune System (Reactome)

PDB 1q8m (A/B/C/D=17-134), 1smo (A/B=21-139)
OPM none
Complexes

TREM1:TREM1_HUMAN

Interactions

TLR4, Complex: TREM1:TLR4, PubMed

TREM1, Complex: Homodimer of triggering receptor expressed on myeloid cells 1, PDBID: 1Q8M

TYOBP, Complex: TYOBP:TREM1, PubMed

Domains

AA: 25-134, PDBID: 1Q8M, Subunit D, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for TREM1_HUMAN » Triggering receptor expressed on myeloid cells 1
FUNCTION: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

SUBUNIT: Interacts with TYROBP/DAP12.

TISSUE SPECIFICITY: Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.

INDUCTION: Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).

UniProt features for TREM1_HUMAN » Triggering receptor expressed on myeloid cells 1
SIGNAL 1 20 Potential.
CHAIN 21 234 Triggering receptor expressed on myeloid cells 1.
DOMAIN 26 134 Ig-like V-type.
DISULFID 41 113
Amino Acid Sequence for TREM1_HUMAN » Triggering receptor expressed on myeloid cells 1
MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK EPHMLFDRIR LVVTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST ADVSTPDSEI NLTNVTDIIR VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP