TRAT1_HUMAN » T-cell receptor-associated transmembrane adapter 1

TRAT1_HUMAN » T-cell receptor-associated transmembrane adapter 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TRAT1_HUMAN » T-cell receptor-associated transmembrane adapter 1 » T-cell receptor-interacting molecule;TRIM; pp29/30;
Hydrophobic Thickness 35.6 ± 1.2 Å
Tilt Angle 3 ± 1°
ΔGtransfer -44.0 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 9-34 (8-40)
Pathways

Immune System (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CD3E, Complex: CD3E:TRAT1, PubMed

CD3Z, Complex: CD3Z:TRAT1, PubMed

HRSL4, Complex: TRAT1:HRSL4, PubMed

Domains

AA: 12-120, SHP2-interacting transmembrane adaptor protein, SIT

UniProt annotation for TRAT1_HUMAN » T-cell receptor-associated transmembrane adapter 1
FUNCTION: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.

SUBUNIT: Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1.

TISSUE SPECIFICITY: Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).

DEVELOPMENTAL STAGE: Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver.

UniProt features for TRAT1_HUMAN » T-cell receptor-associated transmembrane adapter 1
CHAIN 1 186 T-cell receptor-associated transmembrane adapter 1.
REGION 79 82 Interaction with PIK3R1.
DISULFID 7 7 Interchain (Probable).
Amino Acid Sequence for TRAT1_HUMAN » T-cell receptor-associated transmembrane adapter 1
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN