TR19L_HUMAN » Tumor necrosis factor receptor superfamily member 19L

TR19L_HUMAN » Tumor necrosis factor receptor superfamily member 19L
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TR19L_HUMAN » Tumor necrosis factor receptor superfamily member 19L » Receptor expressed in lymphoid tissues;
Hydrophobic Thickness 38.4 ± 3.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -38.7 kcal/mol
ΔGfold -18.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 160-186 (156-189)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

RELL1, Complex: TR19L:RELL1, PubMed

Domains

AA: 163-203, Tumour necrosis factor receptor superfamily member 19

UniProt annotation for TR19L_HUMAN » Tumor necrosis factor receptor superfamily member 19L
FUNCTION: Mediates activation of NF-kappa-B. May play a role in T- cell activation.

SUBUNIT: Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.

TISSUE SPECIFICITY: Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.

UniProt features for TR19L_HUMAN » Tumor necrosis factor receptor superfamily member 19L
SIGNAL 1 25
CHAIN 26 430 Tumor necrosis factor receptor superfamily member 19L.
REPEAT 50 90 TNFR-Cys.
DISULFID 51 65 By similarity.
DISULFID 71 90 By similarity.
Amino Acid Sequence for TR19L_HUMAN » Tumor necrosis factor receptor superfamily member 19L
MKPSLLCRPL SCFLMLLPWP LATLTSTTLW QCPPGEEPDL DPGQGTLCRP CPPGTFSAAW GSSPCQPHAR CSLWRRLEAQ VGMATRDTLC GDCWPGWFGP WGVPRVPCQP CSWAPLGTHG CDEWGRRARR GVEVAAGASS GGETRQPGNG TRAGGPEETA AQYAVIAIVP VFCLMGLLGI LVCNLLKRKG YHCTAHKEVG PGPGGGGSGI NPAYRTEDAN EDTIGVLVRL ITEKKENAAA LEELLKEYHS KQLVQTSHRP VSKLPPAPPN VPHICPHRHH LHTVQGLASL SGPCCSRCSQ KKWPEVLLSP EAVAATTPVP SLLPNPTRVP KAGAKAGRQG EITILSVGRF RVARIPEQRT SSMVSEVKTI TEAGPSWGDL PDSPQPGLPP EQQALLGSGG SRTKWLKPPA ENKAEENRYV VRLSESNLVI