TR13C_HUMAN » Tumor necrosis factor receptor superfamily member 13C

TR13C_HUMAN » Tumor necrosis factor receptor superfamily member 13C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TR13C_HUMAN » Tumor necrosis factor receptor superfamily member 13C » B-cell-activating factor receptor;BAFF receptor;BAFF-R; BLyS receptor 3;
Hydrophobic Thickness 36.0 ± 5.2 Å
Tilt Angle 16 ± 13°
ΔGtransfer -27.7 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 76-102 (75-106)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

HTLV-I infection (KEGG)

Intestinal immune network for IgA production (KEGG)

NF-kappa B signaling pathway (KEGG)

Primary immunodeficiency (KEGG)

PDB 1osx (1-61), 4v46 (1-63), 1oqe (16-46), 1mpv (26-33), 2hfg (R=7-54)
OPM none
Complexes none
Interactions

TN13B, Complex: TN13B:TR13C, PDBID: 1oqe

Domains

AA: 16-45, PDBID: 1MPV, Subunit A, Seq Identity:100%, BAFF-R, TALL-1 binding

UniProt annotation for TR13C_HUMAN » Tumor necrosis factor receptor superfamily member 13C
FUNCTION: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

TISSUE SPECIFICITY: Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

DISEASE: Immunodeficiency, common variable, 4 (CVID4) OMIM: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. mutations affecting the gene represented in this entry.

UniProt features for TR13C_HUMAN » Tumor necrosis factor receptor superfamily member 13C
CHAIN 1 184 Tumor necrosis factor receptor superfamily member 13C.
REPEAT 18 35 TNFR-Cys; truncated.
REGION 26 31 Essential for TNFSF13B/TALL1/BAFF/BLyS binding.
DISULFID 19 32
DISULFID 24 35
Amino Acid Sequence for TR13C_HUMAN » Tumor necrosis factor receptor superfamily member 13C
MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPGLLFG APALLGLALV LALVLVGLVS WRRRQRRLRG ASSAEAPDGD KDAPEPLDKV IILSPGISDA TAPAWPPPGE DPGTTPPGHS VPVPATELGS TELVTTKTAG PEQQ