TR10D_HUMAN » Tumor necrosis factor receptor superfamily member 10D

TR10D_HUMAN » Tumor necrosis factor receptor superfamily member 10D
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Topology in Plasma membrane
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TR10D_HUMAN » Tumor necrosis factor receptor superfamily member 10D » Decoy receptor 2;DcR2; TNF-related apoptosis-inducing ligand receptor 4;TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain;
Hydrophobic Thickness 30.0 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.3 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 210-232 (209-234)
Pathways

Apoptosis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Influenza A (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions

TNF10, Complex: TR10D:TNF10, PubMed

TR10A, Complex: TR10A:TR10D, PubMed

TR10B, Complex: TR10B:TR10D, PubMed

Domains

AA: 99-139, PDBID: 1D0G, Subunit R, Seq Identity:51%, TNFR/NGFR cysteine-rich region

AA: 141-180, PDBID: 1D0G, Subunit R, Seq Identity:73%, TNFR/NGFR cysteine-rich region

UniProt annotation for TR10D_HUMAN » Tumor necrosis factor receptor superfamily member 10D
FUNCTION: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

TISSUE SPECIFICITY: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

UniProt features for TR10D_HUMAN » Tumor necrosis factor receptor superfamily member 10D
SIGNAL 1 55
CHAIN 56 386 Tumor necrosis factor receptor superfamily member 10D.
REPEAT 58 97 TNFR-Cys 1.
REPEAT 98 139 TNFR-Cys 2.
REPEAT 140 180 TNFR-Cys 3.
DOMAIN 340 366 Death; truncated.
DISULFID 83 96 By similarity.
DISULFID 99 115 By similarity.
DISULFID 118 131 By similarity.
DISULFID 121 139 By similarity.
DISULFID 141 155 By similarity.
DISULFID 158 172 By similarity.
DISULFID 162 180 By similarity.
Amino Acid Sequence for TR10D_HUMAN » Tumor necrosis factor receptor superfamily member 10D
MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL