TR10C_HUMAN » Tumor necrosis factor receptor superfamily member 10C

TR10C_HUMAN » Tumor necrosis factor receptor superfamily member 10C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TR10C_HUMAN » Tumor necrosis factor receptor superfamily member 10C » Antagonist decoy receptor for TRAIL/Apo-2L;Decoy TRAIL receptor without death domain;Decoy receptor 1;DcR1; Lymphocyte inhibitor of TRAIL;TNF-related apoptosis-inducing ligand receptor 3;TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular
Hydrophobic Thickness 27.2 ± 3.4 Å
Tilt Angle 5 ± 4°
ΔGtransfer -40.3 kcal/mol
ΔGfold -17.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Und
TM Segments 240-259 (235-259)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 69-109, PDBID: 1D0G, Subunit R, Seq Identity:41%, TNFR/NGFR cysteine-rich region

AA: 111-149, PDBID: 1D0G, Subunit R, Seq Identity:52%, TNFR/NGFR cysteine-rich region

UniProt annotation for TR10C_HUMAN » Tumor necrosis factor receptor superfamily member 10C
FUNCTION: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
UniProt features for TR10C_HUMAN » Tumor necrosis factor receptor superfamily member 10C
SIGNAL 1 25

CHAIN 26 236 Tumor necrosis factor receptor superfamily member 10C.

PROPEP 237 259 Removed in mature form.

REPEAT 29 66 TNFR-Cys 1.

REPEAT 69 109 TNFR-Cys 2.

REPEAT 110 149 TNFR-Cys 3.

REPEAT 162 176 TAPE 1.

REPEAT 177 191 TAPE 2.

REPEAT 192 206 TAPE 3.

REPEAT 207 221 TAPE 4.

REPEAT 222 236 TAPE 5.

DISULFID 53 66

DISULFID 69 85

DISULFID 88 101

DISULFID 91 109

DISULFID 111 125

DISULFID 128 141

DISULFID 131 149

Amino Acid Sequence for TR10C_HUMAN » Tumor necrosis factor receptor superfamily member 10C
MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY LSCTIVGIIV LIVLLIVFV