TR10B_HUMAN » Tumor necrosis factor receptor superfamily member 10B

TR10B_HUMAN » Tumor necrosis factor receptor superfamily member 10B
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Topology in Plasma membrane
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cytoplasmic side
TR10B_HUMAN » Tumor necrosis factor receptor superfamily member 10B » Death receptor 5;TNF-related apoptosis-inducing ligand receptor 2;TRAIL receptor 2; TRAIL-R2;
Hydrophobic Thickness 33.6 ± 3.0 Å
Tilt Angle 12 ± 5°
ΔGtransfer -49.7 kcal/mol
ΔGfold -19.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 208-240 (208-241)
Pathways

Apoptosis (KEGG)

Apoptosis (Reactome)

Cytokine-cytokine receptor interaction (KEGG)

Influenza A (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

p53 signaling pathway (KEGG)

PDB 1du3 (A/B...=54-183), 1d4v (A=69-184), 4i9x (C/D=58-184), 1d0g (R/S/T=54-183), 4n90 (R/S/T=57-182), 1za3 (R/S=54-183), 2h9g (R/S=54-183), 4od2 (S=73-183)
OPM none
Complexes

TNF10:TR10B_HUMAN

Interactions

EGFR, Complex: EGFR:TR10B

TIM50, Complex: TR10B:TIM50, PubMed

TNF10, Complex: TNF10:TR10B, PDBID: 1d0g

TNFL6, Complex: TNFL6:TR10B, PubMed

TNR1A, Complex: TNR1A:TR10B, PubMed

TNR6, Complex: TNR6:TR10B, PubMed

TR10A, Complex: CASP8:TR10B:TR10A:FADD, PubMed

TR10D, Complex: TR10B:TR10D, PubMed

Domains

AA: 97-137, PDBID: 1D0G, Subunit R, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 139-178, PDBID: 1D0G, Subunit R, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 339-422, PDBID: 1ICH, Subunit A, Seq Identity:30%, Death domain

UniProt annotation for TR10B_HUMAN » Tumor necrosis factor receptor superfamily member 10B
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.

SUBUNIT: Homotrimer. Can interact with TRADD and RIPK1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10B cell surface expression. Two TNFRSF10B monomers interact with a UL141 homodimer.

TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

INDUCTION: By ER stress. Regulated by p53/TP53.

DISEASE: Squamous cell carcinoma of the head and neck (HNSCC) OMIM: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.

UniProt features for TR10B_HUMAN » Tumor necrosis factor receptor superfamily member 10B
SIGNAL 1 55
CHAIN 56 440 Tumor necrosis factor receptor superfamily member 10B.
REPEAT 57 94 TNFR-Cys 1.
REPEAT 97 137 TNFR-Cys 2.
REPEAT 138 178 TNFR-Cys 3.
REPEAT 192 206 TAPE.
DOMAIN 339 422 Death.
DISULFID 81 94
DISULFID 97 113
DISULFID 116 129
DISULFID 119 137
DISULFID 139 153
DISULFID 156 170
DISULFID 160 178
Amino Acid Sequence for TR10B_HUMAN » Tumor necrosis factor receptor superfamily member 10B
MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KESGTKHSGE APAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED HLLSSGKFMY LEGNADSAMS