TR10A_HUMAN » Tumor necrosis factor receptor superfamily member 10A

TR10A_HUMAN » Tumor necrosis factor receptor superfamily member 10A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TR10A_HUMAN » Tumor necrosis factor receptor superfamily member 10A » Death receptor 4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1; TRAIL-R1;
Hydrophobic Thickness 34.8 ± 3.0 Å
Tilt Angle 29 ± 22°
ΔGtransfer -27.6 kcal/mol
ΔGfold -20.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 239-265 (238-266)
Pathways

Apoptosis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Influenza A (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions

CD4, Complex: TR10A:CD4, PubMed

TNF10, Complex: TNF10:TR10A, PubMed

TR10B, Complex: CASP8:TR10B:TR10A:FADD, PubMed

TR10D, Complex: TR10A:TR10D, PubMed

Domains

AA: 148-188, PDBID: 1D0G, Subunit R, Seq Identity:57%, TNFR/NGFR cysteine-rich region

AA: 190-229, PDBID: 1D0G, Subunit R, Seq Identity:66%, TNFR/NGFR cysteine-rich region

AA: 367-448, PDBID: 1ICH, Subunit A, Seq Identity:31%, Death domain

UniProt annotation for TR10A_HUMAN » Tumor necrosis factor receptor superfamily member 10A
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

SUBUNIT: Can interact with TRADD and RIPK1. Interacts with ARAP1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10A cell surface expression.

TISSUE SPECIFICITY: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

UniProt features for TR10A_HUMAN » Tumor necrosis factor receptor superfamily member 10A
SIGNAL 1 23 Potential.
CHAIN 24 468 Tumor necrosis factor receptor superfamily member 10A.
REPEAT 107 145 TNFR-Cys 1.
REPEAT 147 188 TNFR-Cys 2.
REPEAT 189 229 TNFR-Cys 3.
DOMAIN 365 448 Death.
DISULFID 132 145 By similarity.
DISULFID 148 164 By similarity.
DISULFID 167 180 By similarity.
DISULFID 170 188 By similarity.
DISULFID 190 204 By similarity.
DISULFID 207 221 By similarity.
DISULFID 211 229 By similarity.
Amino Acid Sequence for TR10A_HUMAN » Tumor necrosis factor receptor superfamily member 10A
MAPPPARVHL GAFLAVTPNP GSAASGTEAA AATPSKVWGS SAGRIEPRGG GRGALPTSMG QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL LQVVPSSAAT IKLHDQSIGT QQWEHSPLGE LCPPGSHRSE HPGACNRCTE GVGYTNASNN LFACLPCTAC KSDEEERSPC TTTRNTACQC KPGTFRNDNS AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHNI WVILVVTLVV PLLLVAVLIV CCCIGSGCGG DPKCMDRVCF WRLGLLRGPG AEDNAHNEIL SNADSLSTFV SEQQMESQEP ADLTGVTVQS PGEAQCLLGP AEAEGSQRRR LLVPANGADP TETLMLFFDK FANIVPFDSW DQLMRQLDLT KNEIDVVRAG TAGPGDALYA MLMKWVNKTG RNASIHTLLD ALERMEERHA KEKIQDLLVD SGKFIYLEDG TGSAVSLE