TPSNR_HUMAN » Tapasin-related protein

TPSNR_HUMAN » Tapasin-related protein
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TPSNR_HUMAN » Tapasin-related protein » TAPASIN-R; TAP-binding protein-like;TAP-binding protein-related protein;TAPBP-R; Tapasin-like;
Hydrophobic Thickness 33.2 ± 2.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -21.9 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 405-426 (402-431)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 195-301, PDBID: 3Q0H, Subunit A, Seq Identity:26%, Immunoglobulin V-set domain

AA: 299-389, PDBID: 2YEZ, Subunit A, Seq Identity:39%, Immunoglobulin C1-set domain

UniProt annotation for TPSNR_HUMAN » Tapasin-related protein
FUNCTION: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.

INDUCTION: By interferon gamma.

UniProt features for TPSNR_HUMAN » Tapasin-related protein
SIGNAL 1 18
CHAIN 19 468 Tapasin-related protein.
DOMAIN 181 297 Ig-like V-type.
DOMAIN 304 394 Ig-like C1-type.
DISULFID 212 283 By similarity.
DISULFID 321 382 By similarity.
Amino Acid Sequence for TPSNR_HUMAN » Tapasin-related protein
MGTQEGWCLL LCLALSGAAE TKPHPAEGQW RAVDVVLDCF LVKDGAHRGA LASSEDRARA SLVLKQVPVL DDGSLEDFTD FQGGTLAQDD PPIIFEASVD LVQIPQAEAL LHADCSGKEV TCEISRYFLQ MTETTVKTAA WFMANVQVSG GGPSISLVMK TPRVAKNEVL WHPTLNLPLS PQGTVRTAVE FQVMTQTQSL SFLLGSSASL DCGFSMAPGL DLISVEWRLQ HKGRGQLVYS WTAGQGQAVR KGATLEPAQL GMARDASLTL PGLTIQDEGT YICQITTSLY RAQQIIQLNI QASPKVRLSL ANEALLPTLI CDIAGYYPLD VVVTWTREEL GGSPAQVSGA SFSSLRQSVA GTYSISSSLT AEPGSAGATY TCQVTHISLE EPLGASTQVV PPERRTALGV IFASSLFLLA LMFLGLQRRQ APTGLGLLQA ERWETTSCAD TQSSHLHEDR TARVSQPS