|TPBG_HUMAN » Trophoblast glycoprotein » 5T4 oncofetal antigen;5T4 oncofetal trophoblast glycoprotein;5T4 oncotrophoblast glycoprotein; M6P1;|
|Hydrophobic Thickness||34.0 ± 1.1 Å|
|Tilt Angle||2 ± 1°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||354-376 (351-379)|
|PDB||4cnc (60-345), 4cnm (60-345)|
|UniProt annotation for TPBG_HUMAN » Trophoblast glycoprotein|
|FUNCTION: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization. TISSUE SPECIFICITY: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. DOMAIN: The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. MISCELLANEOUS: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy. MISCELLANEOUS: Reduction of TPBG levels by siRNA significantly enhanced the beta-catenin/TCF transcription-based reporter pBAR activation in response to Wnt stimulation.|
|UniProt features for TPBG_HUMAN » Trophoblast glycoprotein|
SIGNAL 1 31 Potential. |
CHAIN 32 420 Trophoblast glycoprotein.
DOMAIN 53 91 LRRNT.
REPEAT 92 113 LRR 1.
REPEAT 119 140 LRR 2.
REPEAT 143 164 LRR 3.
REPEAT 211 232 LRR 4.
REPEAT 235 256 LRR 5.
REPEAT 259 280 LRR 6.
DOMAIN 294 346 LRRCT.
|Amino Acid Sequence for TPBG_HUMAN » Trophoblast glycoprotein|
|MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL NHIVPPEDER QNRSFEGMVV AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV|