TOM70_YEAST » Mitochondrial import receptor subunit TOM70

TOM70_YEAST » Mitochondrial import receptor subunit TOM70
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TOM70_YEAST » Mitochondrial import receptor subunit TOM70 » 70 kDa mitochondrial outer membrane protein;Translocase of outer membrane 70 kDa subunit;
Hydrophobic Thickness 26.4 ± 2.6 Å
Tilt Angle 2 ± 2°
ΔGtransfer -24.2 kcal/mol
ΔGfold -8.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 10-28 (9-32)
Pathways

Mitochondrial Protein Import (yeast) (Reactome)

PDB 2gw1 (A/B=94-607)
OPM none
Complexes

TOM70:TOM70_YEAST

Interactions

ANP1, Complex: TOM70:ANP1

BAX, Complex: TOM70:BAX, PubMed

ERP4, Complex: ERP4:TOM70

FCJ1, Complex: TOM70:FCJ1, PubMed

GEM1, Complex: TOM70:GEM1

GMC1, Complex: TOM70:GMC1

KTR4, Complex: KTR4:TOM70

MCR1, Complex: MCR1:TOM70, PubMed

MIA40, Complex: TOM70:MIA40

MMM1, Complex: TOM70:MMM1

MNN10, Complex: MNN10:TOM70

OM45, Complex: TOM70:OM45, PubMed

PSD1, Complex: PSD1:TOM70

SCS2, Complex: TOM70:SCS2

SEC22, Complex: TOM70:SEC22

SLG1, Complex: TOM70:SLG1, PubMed

TAZ1, Complex: TOM70:TAZ1

TIM14, Complex: TOM70:TIM14

TIM50, Complex: TOM70:TIM50, PubMed

TOM20, Complex: TOM20:TOM70

TOM22, Complex: TOM70:TOM22, PubMed

TOM5, Complex: TOM70:TOM5, PubMed

TOM6, Complex: TOM70:TOM6, PubMed

TOM70, Complex: Homodimer of mitochondrial import receptor subunit TOM70, PDBID: 2GW1

TOM71, Complex: TOM70:TOM71, PubMed

UGO1, Complex: UGO1:TOM70, PubMed

YP063, Complex: TOM70:YP063

Domains

AA: 99-132, PDBID: 2GW1, Subunit A, Seq Identity:100%, Tetratricopeptide repeat

UniProt annotation for TOM70_YEAST » Mitochondrial import receptor subunit TOM70
FUNCTION: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.

SUBUNIT: Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex interacts with TOM22. Interacts with TOM37.

MISCELLANEOUS: Present with 45300 molecules/cell in log phase SD medium.

UniProt features for TOM70_YEAST » Mitochondrial import receptor subunit TOM70
CHAIN 1 617 Mitochondrial import receptor subunit TOM70.
REPEAT 99 132 TPR 1.
REPEAT 134 165 TPR 2.
REPEAT 281 315 TPR 3.
REPEAT 363 396 TPR 4.
REPEAT 397 430 TPR 5.
REPEAT 432 464 TPR 6.
REPEAT 465 498 TPR 7.
REPEAT 505 541 TPR 8.
REPEAT 542 575 TPR 9.
Amino Acid Sequence for TOM70_YEAST » Mitochondrial import receptor subunit TOM70
MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK DTKDSQKETE GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL ALKDKGNQFF RNKKYDDAIK YYNWALELKE DPVFYSNLSA CYVSVGDLKK VVEMSTKALE LKPDYSKVLL RRASANEGLG KFADAMFDLS VLSLNGDFND ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP AKERKDKQEN LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH EDIKKAIELF PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY YHRGQMNFIL QNYDQAGKDF DKAKELDPEN IFPYIQLACL AYRENKFDDC ETLFSEAKRK FPEAPEVPNF FAEILTDKND FDKALKQYDL AIELENKLDG IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR SEQAKIGLAQ MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL AKKIQETLAK LREQGLM