TOM70_HUMAN » Mitochondrial import receptor subunit TOM70

TOM70_HUMAN » Mitochondrial import receptor subunit TOM70
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TOM70_HUMAN » Mitochondrial import receptor subunit TOM70 » Mitochondrial precursor proteins import receptor;Translocase of outer membrane 70 kDa subunit;
Hydrophobic Thickness 28.2 ± 3.7 Å
Tilt Angle 8 ± 1°
ΔGtransfer -18.7 kcal/mol
ΔGfold -11.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 39-59 (37-68)
Pathways none
PDB none
OPM none
Complexes

TOM70:TOM70_YEAST

Interactions

MAVS, Complex: TOM70:MAVS, PubMed

PINK1, Complex: TOM70:PINK1, PubMed

TIM50, Complex: TOM70:TIM50, PubMed

TOM20, Complex: TOM70:TOM20, PubMed

TOM22, Complex: TOM22:TOM70, PubMed

TOM7, Complex: TOM7:TOM70, PubMed

Domains

AA: 114-147, PDBID: 4CGV, Subunit A, Seq Identity:52%, Tetratricopeptide repeat

AA: 329-362, PDBID: 2DBA, Subunit A, Seq Identity:30%, Tetratricopeptide repeat

AA: 401-434, PDBID: 4UI9, Subunit Y, Seq Identity:32%, Tetratricopeptide repeat

AA: 476-509, PDBID: 2DBA, Subunit A, Seq Identity:27%, Tetratricopeptide repeat

AA: 547-578, PDBID: 4UI9, Subunit Y, Seq Identity:36%, Tetratricopeptide repeat

UniProt annotation for TOM70_HUMAN » Mitochondrial import receptor subunit TOM70
FUNCTION: Receptor that accelerates the import of all mitochondrial precursor proteins.

SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).

UniProt features for TOM70_HUMAN » Mitochondrial import receptor subunit TOM70
CHAIN 1 608 Mitochondrial import receptor subunit TOM70.
REPEAT 114 147 TPR 1.
REPEAT 153 186 TPR 2.
REPEAT 294 327 TPR 3.
REPEAT 329 362 TPR 4.
REPEAT 367 400 TPR 5.
REPEAT 401 434 TPR 6.
REPEAT 440 475 TPR 7.
REPEAT 476 509 TPR 8.
REPEAT 511 544 TPR 9.
REPEAT 545 578 TPR 10.
Amino Acid Sequence for TOM70_HUMAN » Mitochondrial import receptor subunit TOM70
MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK YGLKPPTL