TOM22_YEAST » Mitochondrial import receptor subunit TOM22

TOM22_YEAST » Mitochondrial import receptor subunit TOM22
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TOM22_YEAST » Mitochondrial import receptor subunit TOM22 » Mitochondrial 17 kDa assembly protein;Mitochondrial 22 kDa outer membrane protein;Protein MAS17;Translocase of outer membrane 22 kDa subunit;
Hydrophobic Thickness 29.4 ± 2.4 Å
Tilt Angle 13 ± 15°
ΔGtransfer -18.6 kcal/mol
ΔGfold -11.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 98-118 (98-128)
Pathways

Mitochondrial Protein Import (yeast) (Reactome)

PDB none
OPM none
Complexes none
Interactions

BAX, Complex: TOM22:BAX, PubMed

BCS1, Complex: BCS1:TOM22, PubMed

CP51, Complex: TOM22:CP51

FCJ1, Complex: FCJ1:TOM22, PubMed

MIA40, Complex: TOM22:MIA40, PubMed

MSP1, Complex: MSP1:TOM22

OM45, Complex: OM45:TOM22, PubMed

PEX13, Complex: PEX13:TOM22, PubMed

PSD1, Complex: PSD1:TOM22

TIM14, Complex: TIM14:TOM22, PubMed

TIM21, Complex: TIM21:TOM22, PubMed

TIM50, Complex: TIM50:TOM22, PubMed

TOM20, Complex: TOM20:TOM22, PubMed

TOM5, Complex: TOM22:TOM5, PubMed

TOM6, Complex: TOM6:TOM22, PubMed

TOM70, Complex: TOM70:TOM22, PubMed

TOM7, Complex: TOM22:TOM7, PubMed

UGO1, Complex: UGO1:TOM22, PubMed

Domains

AA: 1-141, Mitochondrial import receptor subunit Tom22

UniProt annotation for TOM22_YEAST » Mitochondrial import receptor subunit TOM22
FUNCTION: Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.

SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). Interacts with TOM20 and TOM70. Interacts with FCJ1.

DOMAIN: Its cytoplasmic domain associates with the cytoplasmic domains of TOM20 and TOM70. Its intermembrane space domain provides a trans binding site for presequences and the single membrane anchor is required for a stable interaction between the GIP complex proteins.

MISCELLANEOUS: Present with 6610 molecules/cell in log phase SD medium.

UniProt features for TOM22_YEAST » Mitochondrial import receptor subunit TOM22
CHAIN 2 152 Mitochondrial import receptor subunit TOM22.
Amino Acid Sequence for TOM22_YEAST » Mitochondrial import receptor subunit TOM22
MVELTEIKDD VVQLDEPQFS RNQAIVEEKA SATNNDVVDD EDDSDSDFED EFDENETLLD RIVALKDIVP PGKRQTISNF FGFTSSFVRN AFTKSGNLAW TLTTTALLLG VPLSLSILAE QQLIEMEKTF DLQSDANNIL AQGEKDAAAT AN