TOM22_HUMAN » Mitochondrial import receptor subunit TOM22 homolog

TOM22_HUMAN » Mitochondrial import receptor subunit TOM22 homolog
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TOM22_HUMAN » Mitochondrial import receptor subunit TOM22 homolog » hTom22; 1C9-2;Translocase of outer membrane 22 kDa subunit homolog;
Hydrophobic Thickness 29.0 ± 3.2 Å
Tilt Angle 52 ± 0°
ΔGtransfer -25.4 kcal/mol
ΔGfold -10.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 76-105 (73-109)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BAX, Complex: BAX:TOM22, PubMed

EGFR, Complex: TOM22:EGFR

FKBP8, Complex: FKBP8:TOM22, PubMed

PINK1, Complex: PINK1:TOM22, PubMed

TOM20, Complex: TOM40:TOM22:TOM20, PubMed

TOM70, Complex: TOM22:TOM70, PubMed

TOM7, Complex: TOM7:TOM22, PubMed

Domains

AA: 7-121, Mitochondrial import receptor subunit Tom22

UniProt annotation for TOM22_HUMAN » Mitochondrial import receptor subunit TOM22 homolog
FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.

SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).

TISSUE SPECIFICITY: Ubiquitous.

DOMAIN: Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.

UniProt features for TOM22_HUMAN » Mitochondrial import receptor subunit TOM22 homolog
CHAIN 2 142 Mitochondrial import receptor subunit TOM22 homolog.
REGION 41 50 Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complex (By similarity).
REGION 83 103 TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complex (By similarity).
REGION 123 142 C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complex (By similarity).
Amino Acid Sequence for TOM22_HUMAN » Mitochondrial import receptor subunit TOM22 homolog
MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPSLPG KI