TOM20_YEAST » Mitochondrial import receptor subunit TOM20

TOM20_YEAST » Mitochondrial import receptor subunit TOM20
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TOM20_YEAST » Mitochondrial import receptor subunit TOM20 » Mitochondrial 20 kDa outer membrane protein;Protein MAS20;Translocase of outer membrane 20 kDa subunit;
Hydrophobic Thickness 29.0 ± 7.4 Å
Tilt Angle 41 ± 13°
ΔGtransfer -13.6 kcal/mol
ΔGfold -13.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 6-28 (6-34)
Pathways

Mitochondrial Protein Import (yeast) (Reactome)

PDB none
OPM 1om2 (RAT), 3awr (RAT)
Complexes none
Interactions

OM45, Complex: TOM20:OM45

TOM22, Complex: TOM20:TOM22, PubMed

TOM5, Complex: TOM20:TOM5, PubMed

TOM6, Complex: TOM20:TOM6, PubMed

TOM70, Complex: TOM20:TOM70

TOM7, Complex: TOM20:TOM7, PubMed

Domains

AA: 15-148, PDBID: 1OM2, Subunit A, Seq Identity:25%, MAS20 protein import receptor

UniProt annotation for TOM20_YEAST » Mitochondrial import receptor subunit TOM20
FUNCTION: Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.

SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex, interacts with TOM22.

MISCELLANEOUS: Present with 5680 molecules/cell in log phase SD medium.

UniProt features for TOM20_YEAST » Mitochondrial import receptor subunit TOM20
CHAIN 1 183 Mitochondrial import receptor subunit TOM20.
Amino Acid Sequence for TOM20_YEAST » Mitochondrial import receptor subunit TOM20
MSQSNPILRG LAITTAIAAL SATGYAIYFD YQRRNSPQFR KVLRQRAKEQ AKMEEQAKTH AKEVKLQKVT EFLSMELAKD PIPSDPSERE ATFTTNVENG ERLSMQQGKE LEAASKFYKA LTVYPQPADL LGIYQRSIPE AIYEYIILMI AILPPANVAS FVKGVVGSKA ESDAVAEAND IDD