TOM20_HUMAN » Mitochondrial import receptor subunit TOM20 homolog

TOM20_HUMAN » Mitochondrial import receptor subunit TOM20 homolog
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TOM20_HUMAN » Mitochondrial import receptor subunit TOM20 homolog » Mitochondrial 20 kDa outer membrane protein;Outer mitochondrial membrane receptor Tom20;
Hydrophobic Thickness 27.6 ± 3.6 Å
Tilt Angle 2 ± 2°
ΔGtransfer -12.6 kcal/mol
ΔGfold -7.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 6-25 (4-29)
Pathways none
PDB 4apo (D/E=140-145)
OPM 1om2 (RAT), 3awr (RAT)
Complexes none
Interactions

BAX, Complex: BAX:TOM20

BCL2, Complex: BCL2:TOM20, PubMed

CALX, Complex: TOM20:CALX, PubMed

MID49, Complex: TOM20:MID49

MID51, Complex: TOM20:MID51, PubMed

NDUB4, Complex: NDUB4:TOM20, PubMed

PINK1, Complex: PINK1:PRKN2:TOM20, PubMed

R144B, Complex: R144B:TOM20

TOM22, Complex: HSP7C:TOM20:TOM70:TOM22:VDAC1:TOM40, PubMed

TOM22, Complex: TOM40:TOM22:TOM20, PubMed

TOM5, Complex: TOM40:TOM20:TOM5:TOM6:TOM7, PubMed

TOM70, Complex: TOM70:TOM20, PubMed

TOM7, Complex: TOM20:TOM7, PubMed

Domains

AA: 10-124, PDBID: 1OM2, Subunit A, Seq Identity:99%, MAS20 protein import receptor

UniProt annotation for TOM20_HUMAN » Mitochondrial import receptor subunit TOM20 homolog
FUNCTION: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.

UniProt features for TOM20_HUMAN » Mitochondrial import receptor subunit TOM20 homolog
CHAIN 1 145 Mitochondrial import receptor subunit TOM20 homolog.
Amino Acid Sequence for TOM20_HUMAN » Mitochondrial import receptor subunit TOM20 homolog
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE RAGLSKLPDL KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC GQPQQLLQVL QQTLPPPVFQ MLLTKLPTIS QRIVSAQSLA EDDVE