TOIP2_HUMAN » Torsin-1A-interacting protein 2

TOIP2_HUMAN » Torsin-1A-interacting protein 2
Magnify TOIP2_HUMAN » Torsin-1A-interacting protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TOIP2_HUMAN » Torsin-1A-interacting protein 2 » Lumenal domain-like LAP1;
Hydrophobic Thickness 29.4 ± 1.8 Å
Tilt Angle 22 ± 6°
ΔGtransfer -18.1 kcal/mol
ΔGfold -13.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 218-237 (218-241)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 15-469, PDBID: 4TVS, Subunit A, Seq Identity:15%, Lamina-associated polypeptide 1C (LAP1C)

UniProt annotation for TOIP2_HUMAN » Torsin-1A-interacting protein 2
FUNCTION: Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.

SUBUNIT: Interacts with TOR1A and TOR1B (ATP-bound).

UniProt features for TOIP2_HUMAN » Torsin-1A-interacting protein 2
CHAIN 2 470 Torsin-1A-interacting protein 2.
Amino Acid Sequence for TOIP2_HUMAN » Torsin-1A-interacting protein 2
MADSGLREPQ EDSQKDLEND PSVNSQAQET TIIASNAEEA EILHSACGLS KDHQEVETEG PESADTGDKS ESPDEANVGK HPKDKTEDEN KQSFLDGGKG HHLPSENLGK EPLDPDPSHS PSDKVGRADA HLGSSSVALP KEASDGTGAS QEPPTTDSQE AQSPGHSSAG QEGEDTLRRR LLAPEAGSHP QQTQKLEEIK ENAQDTMRQI NKKGFWSYGP VILVVLVVAV VASSVNSYYS SPAQQVPKNP ALEAFLAQFS QLEDKFPGQS SFLWQRGRKF LQKHLNASNP TEPATIIFTA AREGRETLKC LSHHVADAYT SSQKVSPIQI DGAGRTWQDS DTVKLLVDLE LSYGFENGQK AAVVHHFESF PAGSTLIFYK YCDHENAAFK DVALVLTVLL EEETLEASVG PRETEEKVRD LLWAKFTNSD TPTSFNHMDS DKLSGLWSRI SHLVLPVQPV SSIEEQGCLF