TOIP1_HUMAN » Torsin-1A-interacting protein 1

TOIP1_HUMAN » Torsin-1A-interacting protein 1
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Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
TOIP1_HUMAN » Torsin-1A-interacting protein 1 » Lamin-associated protein 1B;LAP1B;
Hydrophobic Thickness 32.0 ± 2.7 Å
Tilt Angle 2 ± 0°
ΔGtransfer -16.3 kcal/mol
ΔGfold -5.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 336-357 (331-357)
Pathways none
PDB 4tvs (A/B=356-583)
OPM none
Complexes none
Interactions

EGFR, Complex: TOIP1:EGFR

ESR1, Complex: ESR1:TOIP1, PubMed

Domains

AA: 195-583, PDBID: 4TVS, Subunit A, Seq Identity:100%, Lamina-associated polypeptide 1C (LAP1C)

UniProt annotation for TOIP1_HUMAN » Torsin-1A-interacting protein 1
FUNCTION: Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.

SUBUNIT: Interacts with ATP1B4. Interacts with TOR1A (ATP-bound). Interacts with TOR1B, TOR2A and TOR3A. Interacts with VIM.

UniProt features for TOIP1_HUMAN » Torsin-1A-interacting protein 1
CHAIN 1 583 Torsin-1A-interacting protein 1.
COILED 359 435 Potential.
Amino Acid Sequence for TOIP1_HUMAN » Torsin-1A-interacting protein 1
MAGDGRRAEA VREGWGVYVT PRAPIREGRG RLAPQNGGSS DAPAYRTPPS RQGRREVRFS DEPPEVYGDF EPLVAKERSP VGKRTRLEEF RSDSAKEEVR ESAYYLRSRQ RRQPRPQETE EMKTRRTTRL QQQHSEQPPL QPSPVMTRRG LRDSHSSEED EASSQTDLSQ TISKKTVRSI QEAPVSEDLV IRLRRPPLRY PRYEATSVQQ KVNFSEEGET EEDDQDSSHS SVTTVKARSR DSDESGDKTT RSSSQYIESF WQSSQSQNFT AHDKQPSVLS SGYQKTPQEW APQTARIRTR MQNDSILKSE LGNQSPSTSS RQVTGQPQNA SFVKRNRWWL LPLIAALASG SFWFFSTPEV ETTAVQEFQN QMNQLKNKYQ GQDEKLWKRS QTFLEKHLNS SHPRSQPAIL LLTAARDAEE ALRCLSEQIA DAYSSFRSVR AIRIDGTDKA TQDSDTVKLE VDQELSNGFK NGQNAAVVHR FESFPAGSTL IFYKYCDHEN AAFKDVALVL TVLLEEETLG TSLGLKEVEE KVRDFLKVKF TNSNTPNSYN HMDPDKLNGL WSRISHLVLP VQPENALKRG ICL