TO204_ARATH » Mitochondrial import receptor subunit TOM20-4

TO204_ARATH » Mitochondrial import receptor subunit TOM20-4
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
TO204_ARATH » Mitochondrial import receptor subunit TOM20-4 » Translocase of outer membrane 20 kDa subunit 4;
Hydrophobic Thickness 32.2 ± 3.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -13.8 kcal/mol
ΔGfold -11.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 157-178 (155-181)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ATL57, Complex: TO204:ATL57

Domains

AA: 7-179, PDBID: 1ZU2, Subunit A, Seq Identity:54%, Plant specific mitochondrial import receptor subunit TOM20

UniProt annotation for TO204_ARATH » Mitochondrial import receptor subunit TOM20-4
FUNCTION: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.

SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 6 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22/TOM9 and TOM40). Interacts with a variety of mitochondrial precursor proteins.

TISSUE SPECIFICITY: Expressed in roots, flowers, young cotyledons and leaves.

INDUCTION: Up-regulated after antimycin A or rotenone treatments.

MISCELLANEOUS: There are four genes (TOM20-1, TOM20-2, TOM20-3 and TOM20-4) which encode mitochondrial import receptor subunits TOM20.

MISCELLANEOUS: In mammals and fungi, the transmembrane domain is located at the N-terminus while it is located at the C-terminus in plants. The overall orientation of the protein in the membrane is therefore inverted.

UniProt features for TO204_ARATH » Mitochondrial import receptor subunit TOM20-4
CHAIN 1 187 Mitochondrial import receptor subunit TOM20-4.
REPEAT 84 117 TPR.
Amino Acid Sequence for TO204_ARATH » Mitochondrial import receptor subunit TOM20-4
MDMQNENERL MVFEHARKVA EATYVKNPLD AENLTRWAGA LLELSQFQTE PKQMILEAIL KLGEALVIDP KKHDALWLIG NAHLSFGFLS SDQTEASDNF EKASQFFQLA VEEQPESELY RKSLTLASKA PELHTGGTAG PSSNSAKTMK QKKTSEFKYD VFGWVILASY VVAWISFANS QTPVSRQ