TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8

TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8
Magnify TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8 » CD30L receptor;Ki-1 antigen;Lymphocyte activation antigen CD30;
Hydrophobic Thickness 34.0 ± 2.8 Å
Tilt Angle 15 ± 10°
ΔGtransfer -21.9 kcal/mol
ΔGfold -17.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 384-406 (384-413)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 1d01 (G/H/I=576-583)
OPM 1d01
Complexes none
Interactions

ALK, Complex: TNR8:ALK, PubMed

TNFL8, Complex: TNR8:TNFL8, PubMed

Domains

AA: 108-149, PDBID: 3ALQ, Subunit U, Seq Identity:39%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8
FUNCTION: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.

SUBUNIT: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.

MISCELLANEOUS: Most specific Hodgkin disease associated antigen.

UniProt features for TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8
SIGNAL 1 18
CHAIN 19 595 Tumor necrosis factor receptor superfamily member 8.
REPEAT 28 66 TNFR-Cys 1.
REPEAT 68 106 TNFR-Cys 2.
REPEAT 107 150 TNFR-Cys 3.
REPEAT 205 241 TNFR-Cys 4.
REPEAT 243 281 TNFR-Cys 5.
REPEAT 282 325 TNFR-Cys 6.
DISULFID 29 44 By similarity.
DISULFID 45 58 By similarity.
DISULFID 48 65 By similarity.
DISULFID 69 81 By similarity.
DISULFID 84 98 By similarity.
DISULFID 87 106 By similarity.
DISULFID 108 122 By similarity.
DISULFID 131 149 By similarity.
DISULFID 233 240 By similarity.
DISULFID 244 256 By similarity.
DISULFID 259 273 By similarity.
DISULFID 262 281 By similarity.
DISULFID 283 297 By similarity.
DISULFID 289 300 By similarity.
Amino Acid Sequence for TNR8_HUMAN » Tumor necrosis factor receptor superfamily member 8
MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPAGMIVKFP GTAQKNTVCE PASPGVSPAC ASPENCKEPS SGTIPQAKPT PVSPATSSAS TMPVRGGTRL AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC RKQCEPDYYL DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP TQSLLVDSQA SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG SSAFLLCHRR ACRKRIRQKL HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG ASVTEPVAEE RGLMSQPLME TCHSVGAAYL ESLPLQDASP AGGPSSPRDL PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL AGPAEPELEE ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK