TNR6_HUMAN » Tumor necrosis factor receptor superfamily member 6

TNR6_HUMAN » Tumor necrosis factor receptor superfamily member 6
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Topology in Plasma membrane
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cytoplasmic side
TNR6_HUMAN » Tumor necrosis factor receptor superfamily member 6 » Apo-1 antigen;Apoptosis-mediating surface antigen FAS;FASLG receptor;
Hydrophobic Thickness 31.6 ± 2.6 Å
Tilt Angle 3 ± 2°
ΔGtransfer -20.5 kcal/mol
ΔGfold -9.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 173-194 (167-197)
Pathways

5-aminoimidazole ribonucleotide biosynthesis I (BioCyc)

African trypanosomiasis (KEGG)

Allograft rejection (KEGG)

Alzheimer's disease (KEGG)

Apoptosis (Reactome)

Apoptosis (KEGG)

Autoimmune thyroid disease (KEGG)

Chagas disease (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

fatty acid biosynthesis initiation II (BioCyc)

Graft-versus-host disease (KEGG)

Hepatitis B (KEGG)

Herpes simplex infection (KEGG)

Influenza A (KEGG)

MAPK signaling pathway (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

p53 signaling pathway (KEGG)

palmitate biosynthesis I (animals) (BioCyc)

Pathways in cancer (KEGG)

Proteoglycans in cancer (KEGG)

purine nucleotides de novo biosynthesis II (BioCyc)

TNF signaling pathway (KEGG)

Type I diabetes mellitus (KEGG)

PDB 1ddf (218-335), 3ezq (A/C...=223-335), 3ewt (E=230-254), 3thm (F=17-172), 3tje (F=17-172)
OPM none
Complexes none
Interactions

EGFR, Complex: TNR6:EGFR, PubMed

MET, Complex: TNR6:MET, PubMed

TMX1, Complex: TMX1:TNR6, PubMed

TNFA, Complex: TNFA:TNR6, PubMed

TNFL6, Complex: TNFL6:TNR6, PDBID: 1bzi

TNR1A, Complex: TNR1A:TNR6, PubMed

TR10B, Complex: TNR6:TR10B, PubMed

Domains

AA: 85-127, PDBID: 3THM, Subunit F, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 129-165, PDBID: 3TJE, Subunit F, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 230-314, PDBID: 1DDF, Subunit A, Seq Identity:100%, Death domain

UniProt annotation for TNR6_HUMAN » Tumor necrosis factor receptor superfamily member 6
FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

SUBUNIT: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).

TISSUE SPECIFICITY: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

DOMAIN: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

DISEASE: Autoimmune lymphoproliferative syndrome 1A (ALPS1A) OMIM: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. mutations affecting the gene represented in this entry.

UniProt features for TNR6_HUMAN » Tumor necrosis factor receptor superfamily member 6
SIGNAL 1 25 Potential.
CHAIN 26 335 Tumor necrosis factor receptor superfamily member 6.
REPEAT 47 83 TNFR-Cys 1.
REPEAT 84 127 TNFR-Cys 2.
REPEAT 128 166 TNFR-Cys 3.
DOMAIN 230 314 Death.
REGION 212 317 Interaction with HIPK3 (By similarity).
DISULFID 59 73 By similarity.
DISULFID 63 82 By similarity.
DISULFID 85 101 By similarity.
DISULFID 104 119 By similarity.
DISULFID 107 127 By similarity.
DISULFID 129 143 By similarity.
DISULFID 146 157 By similarity.
DISULFID 149 165 By similarity.
Amino Acid Sequence for TNR6_HUMAN » Tumor necrosis factor receptor superfamily member 6
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM TLSQVKGFVR KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV