TNR5_HUMAN » Tumor necrosis factor receptor superfamily member 5

TNR5_HUMAN » Tumor necrosis factor receptor superfamily member 5
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Topology in Plasma membrane
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TNR5_HUMAN » Tumor necrosis factor receptor superfamily member 5 » B-cell surface antigen CD40;Bp50;CD40L receptor;CDw40;
Hydrophobic Thickness 32.8 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.3 kcal/mol
ΔGfold -26.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 191-219 (188-221)
Pathways

Allograft rejection (KEGG)

Asthma (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Epstein-Barr virus infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Malaria (KEGG)

NF-kappa B signaling pathway (KEGG)

Primary immunodeficiency (KEGG)

Systemic lupus erythematosus (KEGG)

Toll-like receptor signaling pathway (KEGG)

Toxoplasmosis (KEGG)

Transcriptional misregulation in cancer (KEGG)

Viral myocarditis (KEGG)

PDB 1lb6 (B=230-236), 1czz (D/E=250-258), 1d00 (I/J...=250-254), 3qd6 (R/S/T/U=21-190), 1fll (X/Y=246-266)
OPM none
Complexes

TNR5:CD40L_HUMAN

Interactions

CD40L, Complex: CD40L:TNR5, PDBID: 3qd6, PubMed

IL4RA, Complex: IL4RA:TNR5:JAK3, PubMed

PCD16, Complex: TNR5:PCD16, PubMed

TN13B, Complex: TN13B:TNR5, PubMed

UD11, Complex: UD11:TNR5, PubMed

Domains

AA: 62-103, PDBID: 3QD6, Subunit S, Seq Identity:100%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR5_HUMAN » Tumor necrosis factor receptor superfamily member 5
FUNCTION: Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

SUBUNIT: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.

TISSUE SPECIFICITY: B-cells and in primary carcinomas.

DISEASE: Immunodeficiency with hyper-IgM 3 (HIGM3) OMIM: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. mutations affecting the gene represented in this entry.

UniProt features for TNR5_HUMAN » Tumor necrosis factor receptor superfamily member 5
SIGNAL 1 20
CHAIN 21 277 Tumor necrosis factor receptor superfamily member 5.
REPEAT 25 60 TNFR-Cys 1.
REPEAT 61 103 TNFR-Cys 2.
REPEAT 104 144 TNFR-Cys 3.
REPEAT 145 187 TNFR-Cys 4.
DISULFID 26 37
DISULFID 38 51
DISULFID 41 59
DISULFID 62 77
DISULFID 83 103
DISULFID 105 119
DISULFID 111 116
DISULFID 125 143
Amino Acid Sequence for TNR5_HUMAN » Tumor necrosis factor receptor superfamily member 5
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLRALVVIPI IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ