TNR4_HUMAN » Tumor necrosis factor receptor superfamily member 4

TNR4_HUMAN » Tumor necrosis factor receptor superfamily member 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR4_HUMAN » Tumor necrosis factor receptor superfamily member 4 » ACT35 antigen;OX40L receptor;TAX transcriptionally-activated glycoprotein 1 receptor;
Hydrophobic Thickness 38.8 ± 3.6 Å
Tilt Angle 1 ± 2°
ΔGtransfer -29.0 kcal/mol
ΔGfold -20.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 214-240 (213-244)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 1d0a (G/H...=262-266), 2hey (R/T=29-170), 2hev (R=29-170)
OPM none
Complexes

TNFL4:TNR4_MOUSE

Interactions

TNFL4, Complex: TNFL4:TNR4, PDBID: 2hev, PubMed

TNR9, Complex: TNR4:TNR9, PubMed

Domains

AA: 31-64, PDBID: 2HEV, Subunit R, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 67-107, PDBID: 2HEV, Subunit R, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 128-166, PDBID: 2HEV, Subunit R, Seq Identity:100%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR4_HUMAN » Tumor necrosis factor receptor superfamily member 4
FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5.

DISEASE: Immunodeficiency 16 (IMD16) OMIM: An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. mutations affecting the gene represented in this entry.

UniProt features for TNR4_HUMAN » Tumor necrosis factor receptor superfamily member 4
SIGNAL 1 28 Potential.
CHAIN 29 277 Tumor necrosis factor receptor superfamily member 4.
REPEAT 30 65 TNFR-Cys 1.
REPEAT 66 107 TNFR-Cys 2.
REPEAT 108 126 TNFR-Cys 3; truncated.
REPEAT 127 167 TNFR-Cys 4.
DISULFID 31 42
DISULFID 43 56
DISULFID 46 64
DISULFID 67 81
DISULFID 84 99
DISULFID 87 107
DISULFID 109 125
DISULFID 128 141
DISULFID 147 166 By similarity.
Amino Acid Sequence for TNR4_HUMAN » Tumor necrosis factor receptor superfamily member 4
MCVGARRLGR GPCAALLLLG LGLSTVTGLH CVGDTYPSND RCCHECRPGN GMVSRCSRSQ NTVCRPCGPG FYNDVVSSKP CKPCTWCNLR SGSERKQLCT ATQDTVCRCR AGTQPLDSYK PGVDCAPCPP GHFSPGDNQA CKPWTNCTLA GKHTLQPASN SSDAICEDRD PPATQPQETQ GPPARPITVQ PTEAWPRTSQ GPSTRPVEVP GGRAVAAILG LGLVLGLLGP LAILLALYLL RRDQRLPPDA HKPPGGGSFR TPIQEEQADA HSTLAKI