TNR3_HUMAN » Tumor necrosis factor receptor superfamily member 3

TNR3_HUMAN » Tumor necrosis factor receptor superfamily member 3
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TNR3_HUMAN » Tumor necrosis factor receptor superfamily member 3 » Lymphotoxin-beta receptor;Tumor necrosis factor C receptor;Tumor necrosis factor receptor 2-related protein;Tumor necrosis factor receptor type III;TNF-RIII; TNFR-III;
Hydrophobic Thickness 36.0 ± 1.8 Å
Tilt Angle 3 ± 0°
ΔGtransfer -54.5 kcal/mol
ΔGfold -24.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 219-247 (219-251)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

HIF-1 signaling pathway (KEGG)

HTLV-I infection (KEGG)

Intestinal immune network for IgA production (KEGG)

NF-kappa B signaling pathway (KEGG)

Viral carcinogenesis (KEGG)

PDB 1rf3 (B=385-408), 4mxw (R/S=41-211)
OPM none
Complexes

TNFB:TNR3:TNFC_HUMAN

Interactions

ITAD, Complex: TNR3:ITAD, PubMed

ITAL, Complex: ITAL:TNR3, PubMed

ITAM, Complex: ITAM:TNR3, PubMed

ITAX, Complex: TNR3:ITAX, PubMed

TNF14, Complex: TRAF3:TNR3:DBLOH:TRAF2:BIRC2:TNF14, PubMed

TNFA, Complex: TNFA:TNR3, PubMed

TNFC, Complex: TNFB:TNR3:TNFC, PDBID: 4mxw, PubMed

Domains

AA: 43-80, PDBID: 4MXW, Subunit S, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 83-124, PDBID: 4MXW, Subunit S, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 163-210, PDBID: 4MXW, Subunit R, Seq Identity:100%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR3_HUMAN » Tumor necrosis factor receptor superfamily member 3
FUNCTION: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

SUBUNIT: Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.

UniProt features for TNR3_HUMAN » Tumor necrosis factor receptor superfamily member 3
SIGNAL 1 30 Potential.
CHAIN 31 435 Tumor necrosis factor receptor superfamily member 3.
REPEAT 42 81 TNFR-Cys 1.
REPEAT 82 124 TNFR-Cys 2.
REPEAT 125 168 TNFR-Cys 3.
REPEAT 169 211 TNFR-Cys 4.
DISULFID 43 58 By similarity.
DISULFID 59 72 By similarity.
DISULFID 62 80 By similarity.
DISULFID 83 98 By similarity.
DISULFID 101 116 By similarity.
DISULFID 104 124 By similarity.
DISULFID 126 132 By similarity.
DISULFID 139 148 By similarity.
DISULFID 142 167 By similarity.
DISULFID 170 185 By similarity.
Amino Acid Sequence for TNR3_HUMAN » Tumor necrosis factor receptor superfamily member 3
MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA TPSNRGPRNQ FITHD