TNR27_HUMAN » Tumor necrosis factor receptor superfamily member 27

TNR27_HUMAN » Tumor necrosis factor receptor superfamily member 27
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR27_HUMAN » Tumor necrosis factor receptor superfamily member 27 » X-linked ectodysplasin-A2 receptor;EDA-A2 receptor;
Hydrophobic Thickness 34.8 ± 5.2 Å
Tilt Angle 22 ± 12°
ΔGtransfer -28.7 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 139-163 (134-163)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

EDA, Complex: EDA:TNR27, PubMed

Domains

AA: 3-41, PDBID: 3ALQ, Subunit U, Seq Identity:28%, TNFR/NGFR cysteine-rich region

AA: 44-83, PDBID: 3K51, Subunit B, Seq Identity:37%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR27_HUMAN » Tumor necrosis factor receptor superfamily member 27
FUNCTION: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

SUBUNIT: Associates with TRAF1, TRAF3 and TRAF6.

UniProt features for TNR27_HUMAN » Tumor necrosis factor receptor superfamily member 27
CHAIN 1 297 Tumor necrosis factor receptor superfamily member 27.
REPEAT 2 41 TNFR-Cys 1.
REPEAT 43 83 TNFR-Cys 2.
REPEAT 85 118 TNFR-Cys 3.
DISULFID 3 15 By similarity.
DISULFID 18 31 By similarity.
DISULFID 21 41 By similarity.
DISULFID 44 58 By similarity.
DISULFID 61 75 By similarity.
DISULFID 64 83 By similarity.
DISULFID 86 104 By similarity.
DISULFID 107 118 By similarity.
Amino Acid Sequence for TNR27_HUMAN » Tumor necrosis factor receptor superfamily member 27
MDCQENEYWD QWGRCVTCQR CGPGQELSKD CGYGEGGDAY CTACPPRRYK SSWGHHRCQS CITCAVINRV QKVNCTATSN AVCGDCLPRF YRKTRIGGLQ DQECIPCTKQ TPTSEVQCAF QLSLVEADAP TVPPQEATLV ALVSSLLVVF TLAFLGLFFL YCKQFFNRHC QRGGLLQFEA DKTAKEESLF PVPPSKETSA ESQVSENIFQ TQPLNPILED DCSSTSGFPT QESFTMASCT SESHSHWVHS PIECTELDLQ KFSSSASYTG AETLGGNTVE STGDRLELNV PFEVPSP