TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25

TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25
Magnify TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25 » Apo-3;Apoptosis-inducing receptor AIR;Apoptosis-mediating receptor DR3;Apoptosis-mediating receptor TRAMP;Death receptor 3;Lymphocyte-associated receptor of death;LARD; Protein WSL;Protein WSL-1;
Hydrophobic Thickness 34.0 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -34.0 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 199-223 (197-226)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

TNF12, Complex: TNF12:TNR25, PubMed

TNF15, Complex: TNR25:TNF15, PubMed

TNR1A, Complex: TNR25:TNR1A, PubMed

Domains

AA: 73-115, PDBID: 1JMA, Subunit B, Seq Identity:38%, TNFR/NGFR cysteine-rich region

AA: 333-413, PDBID: 1ICH, Subunit A, Seq Identity:43%, Death domain

UniProt annotation for TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25
FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

SUBUNIT: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

TISSUE SPECIFICITY: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

UniProt features for TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25
SIGNAL 1 24 Potential.
CHAIN 25 417 Tumor necrosis factor receptor superfamily member 25.
REPEAT 34 71 TNFR-Cys 1.
REPEAT 72 115 TNFR-Cys 2.
REPEAT 116 163 TNFR-Cys 3.
REPEAT 164 192 TNFR-Cys 4.
DOMAIN 332 413 Death.
DISULFID 35 47 By similarity.
DISULFID 48 61 By similarity.
DISULFID 51 70 By similarity.
DISULFID 73 89 By similarity.
DISULFID 92 107 By similarity.
DISULFID 95 115 By similarity.
DISULFID 117 130 By similarity.
DISULFID 138 155 By similarity.
DISULFID 141 162 By similarity.
DISULFID 165 176 By similarity.
DISULFID 179 191 By similarity.
DISULFID 187 195 By similarity.
Amino Acid Sequence for TNR25_HUMAN » Tumor necrosis factor receptor superfamily member 25
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG MEALTPPPAT HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF VRTLGLREAE IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM GLDGCVEDLR SRLQRGP