TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1B

TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1B
Magnify TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1BEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1B » Tumor necrosis factor receptor 2;TNF-R2; Tumor necrosis factor receptor type II;TNF-RII; TNFR-II; p75;p80 TNF-alpha receptor;
Hydrophobic Thickness 35.2 ± 3.2 Å
Tilt Angle 37 ± 6°
ΔGtransfer -24.6 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 257-286 (257-290)
Pathways

Adipocytokine signaling pathway (KEGG)

Amyotrophic lateral sclerosis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

TNF signaling pathway (KEGG)

PDB 1ca9 (G/H=420-428), 3alq (R/S...=33-205)
OPM none
Complexes

TNR1B:TNFA_HUMAN

Interactions

ADA17, Complex: ADA17:TNR1B

ATD3A, Complex: TNR1B:ATD3A, PubMed

OST48, Complex: TNR1B:OST48, PubMed

PLS4, Complex: PLS4:TNR1B, PubMed

SSRD, Complex: SSRD:TNR1B, PubMed

TIM50, Complex: TNR1B:TIM50, PubMed

TNF10, Complex: TNR1B:TNF10

TNFA, Complex: TNR1B:TNFA, PDBID: 3alq, PubMed

TNR1A, Complex: TNR1A:TNR1B, PubMed

TNR1A, Complex: TRAF2:FBW1B:FBW1A:TNR1A:TRADD:TBK1:RASA3:TNR1B:PSMD2

Domains

AA: 40-75, PDBID: 3ALQ, Subunit U, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 78-118, PDBID: 3ALQ, Subunit U, Seq Identity:100%, TNFR/NGFR cysteine-rich region

AA: 120-161, PDBID: 3ALQ, Subunit U, Seq Identity:100%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1B
FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

SUBUNIT: Binds to TRAF2. Interacts with BMX.

UniProt features for TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1B
SIGNAL 1 22
CHAIN 23 461 Tumor necrosis factor receptor superfamily member 1b, membrane form.
CHAIN 27 ? Tumor necrosis factor-binding protein 2.
REPEAT 39 76 TNFR-Cys 1.
REPEAT 77 118 TNFR-Cys 2.
REPEAT 119 162 TNFR-Cys 3.
REPEAT 163 201 TNFR-Cys 4.
DISULFID 40 53 By similarity.
DISULFID 54 67 By similarity.
DISULFID 57 75 By similarity.
DISULFID 78 93 By similarity.
DISULFID 96 110 By similarity.
DISULFID 100 118 By similarity.
DISULFID 120 126 By similarity.
DISULFID 134 143 By similarity.
DISULFID 137 161 By similarity.
DISULFID 164 179 By similarity.
Amino Acid Sequence for TNR1B_HUMAN » Tumor necrosis factor receptor superfamily member 1B
MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S