TNR19_HUMAN » Tumor necrosis factor receptor superfamily member 19

TNR19_HUMAN » Tumor necrosis factor receptor superfamily member 19
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR19_HUMAN » Tumor necrosis factor receptor superfamily member 19 » TRADE;Toxicity and JNK inducer;
Hydrophobic Thickness 34.8 ± 2.2 Å
Tilt Angle 8 ± 4°
ΔGtransfer -40.9 kcal/mol
ΔGfold -23.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 169-195 (165-200)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

LIGO1, Complex: TNR19:LIGO1, PubMed

Domains

AA: 34-72, PDBID: 3ALQ, Subunit U, Seq Identity:33%, TNFR/NGFR cysteine-rich region

AA: 75-114, PDBID: 3ALQ, Subunit U, Seq Identity:31%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR19_HUMAN » Tumor necrosis factor receptor superfamily member 19
FUNCTION: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

SUBUNIT: Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.

TISSUE SPECIFICITY: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

UniProt features for TNR19_HUMAN » Tumor necrosis factor receptor superfamily member 19
SIGNAL 1 29
CHAIN 30 423 Tumor necrosis factor receptor superfamily member 19.
REPEAT 33 72 TNFR-Cys 1.
REPEAT 74 114 TNFR-Cys 2.
REPEAT 116 149 TNFR-Cys 3.
DISULFID 34 46 By similarity.
DISULFID 49 62 By similarity.
DISULFID 52 72 By similarity.
DISULFID 75 89 By similarity.
DISULFID 92 106 By similarity.
DISULFID 95 114 By similarity.
DISULFID 117 135 By similarity.
DISULFID 138 149 By similarity.
Amino Acid Sequence for TNR19_HUMAN » Tumor necrosis factor receptor superfamily member 19
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN QCGPGMELSK ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR FQKANCSATS DAICGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCA SKVNLVKIAS TASSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD SVQTCGPVRL LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN SSQDLVGGAV PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ ESGAVIHPAT QTSLQVRQRL GSL