TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18

TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18 » Activation-inducible TNFR family receptor;Glucocorticoid-induced TNFR-related protein;
Hydrophobic Thickness 37.6 ± 1.4 Å
Tilt Angle 7 ± 4°
ΔGtransfer -38.8 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 162-187 (162-195)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

TNF18, Complex: TNR18:TNF18, PubMed

Domains none
UniProt annotation for TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18
FUNCTION: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

SUBUNIT: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

TISSUE SPECIFICITY: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

INDUCTION: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

UniProt features for TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18
SIGNAL 1 25
CHAIN 26 241 Tumor necrosis factor receptor superfamily member 18.
REPEAT 34 72 TNFR-Cys 1.
REPEAT 74 112 TNFR-Cys 2.
REPEAT 115 153 TNFR-Cys 3.
DISULFID 34 49 By similarity.
DISULFID 74 86 By similarity.
DISULFID 81 94 By similarity.
DISULFID 115 134 By similarity.
DISULFID 128 153 By similarity.
Amino Acid Sequence for TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18
MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC RVHTTRCCRD YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV QSQGKFSFGF QCIDCASGTF SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN AVCVPGSPPA EPLGWLTVVL LAVAACVLLL TSAQLGLHIW QLRSQCMWPR ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW V