|TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18 » Activation-inducible TNFR family receptor;Glucocorticoid-induced TNFR-related protein;|
|Hydrophobic Thickness||30.0 ± 5.6 Å|
|Tilt Angle||51 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||162-187 (162-195)|
|UniProt annotation for TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18|
|FUNCTION: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. SUBUNIT: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA. TISSUE SPECIFICITY: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. INDUCTION: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.|
|UniProt features for TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18|
SIGNAL 1 25 |
CHAIN 26 241 Tumor necrosis factor receptor superfamily member 18.
REPEAT 34 72 TNFR-Cys 1.
REPEAT 74 112 TNFR-Cys 2.
REPEAT 115 153 TNFR-Cys 3.
DISULFID 34 49 By similarity.
DISULFID 74 86 By similarity.
DISULFID 81 94 By similarity.
DISULFID 115 134 By similarity.
DISULFID 128 153 By similarity.
|Amino Acid Sequence for TNR18_HUMAN » Tumor necrosis factor receptor superfamily member 18|
|MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC RVHTTRCCRD YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV QSQGKFSFGF QCIDCASGTF SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN AVCVPGSPPA EPLGWLTVVL LAVAACVLLL TSAQLGLHIW QLRSQCMWPR ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW V|