TNR17_HUMAN » Tumor necrosis factor receptor superfamily member 17

TNR17_HUMAN » Tumor necrosis factor receptor superfamily member 17
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR17_HUMAN » Tumor necrosis factor receptor superfamily member 17 » B-cell maturation protein;
Hydrophobic Thickness 34.8 ± 3.0 Å
Tilt Angle 34 ± 3°
ΔGtransfer -29.6 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 54-80 (52-83)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Intestinal immune network for IgA production (KEGG)

PDB 2kn1 (2-50), 1oqd (8-46), 1xu2 (R/S/T=5-51)
OPM none
Complexes none
Interactions

TN13B, Complex: TN13B:TNR17, PDBID: 1oqd, PubMed

Domains

AA: 8-45, PDBID: 1OQD, Subunit R, Seq Identity:100%, BCMA, TALL-1 binding

UniProt annotation for TNR17_HUMAN » Tumor necrosis factor receptor superfamily member 17
FUNCTION: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

SUBUNIT: Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

TISSUE SPECIFICITY: Expressed in mature B-cells, but not in T- cells or monocytes.

DISEASE: Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

UniProt features for TNR17_HUMAN » Tumor necrosis factor receptor superfamily member 17
CHAIN 1 184 Tumor necrosis factor receptor superfamily member 17.
REPEAT 7 41 TNFR-Cys.
SITE 3 4 Breakpoint for translocation to form IL2/TNFRSF17 oncogene.
DISULFID 8 21
DISULFID 24 37
DISULFID 28 41
Amino Acid Sequence for TNR17_HUMAN » Tumor necrosis factor receptor superfamily member 17
MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNAILWTCL GLSLIISLAV FVLMFLLRKI SSEPLKDEFK NTGSGLLGMA NIDLEKSRTG DEIILPRGLE YTVEECTCED CIKSKPKVDS DHCFPLPAME EGATILVTTK TNDYCKSLPA ALSATEIEKS ISAR