TNR16_HUMAN » Tumor necrosis factor receptor superfamily member 16

TNR16_HUMAN » Tumor necrosis factor receptor superfamily member 16
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Topology in Plasma membrane
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TNR16_HUMAN » Tumor necrosis factor receptor superfamily member 16 » Gp80-LNGFR;Low affinity neurotrophin receptor p75NTR;Low-affinity nerve growth factor receptor;NGF receptor; p75 ICD;
Hydrophobic Thickness 27.2 ± 4.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -20.5 kcal/mol
ΔGfold -14.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 251-272 (251-273)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Neurotrophin signaling pathway (KEGG)

PI3K-Akt signaling pathway (KEGG)

Signal Transduction (Reactome)

Transcriptional misregulation in cancer (KEGG)

PDB 3ewv (E=396-412)
OPM 2mic (RAT), 2mjo (RAT)
Complexes

TNR16:TNR16_RAT

Interactions

A4, Complex: A4:TNR16, PubMed

CD80, Complex: CD80:TNR16

LIGO1, Complex: LIGO1:TNR16:RTN4R

LIGO1, Complex: LIGO1:TNR16, PubMed

MAG, Complex: TNR16:MAG, PubMed

NTRK1, Complex: TNR16:NTRK1, PubMed

NTRK2, Complex: NTRK2:TNR16, PubMed

NTRK3, Complex: NTRK3:TNR16, PubMed

SORC2, Complex: TNR16:SORC2

SORT, Complex: SORT:TNR16, PubMed

TNR16, Complex: Transmembrane homodimer of tumor necrosis factor receptor 16, PDBID: 2MIC

Domains

AA: 109-146, PDBID: 1SG1, Subunit X, Seq Identity:90%, TNFR/NGFR cysteine-rich region

AA: 149-188, PDBID: 1SG1, Subunit X, Seq Identity:95%, TNFR/NGFR cysteine-rich region

AA: 344-421, PDBID: 2N80, Subunit A, Seq Identity:100%, Death domain

UniProt annotation for TNR16_HUMAN » Tumor necrosis factor receptor superfamily member 16
FUNCTION: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts (via death domain) with RAB31. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1.

DOMAIN: Death domain is responsible for interaction with RANBP9.

DOMAIN: The extracellular domain is responsible for interaction with NTRK1.

UniProt features for TNR16_HUMAN » Tumor necrosis factor receptor superfamily member 16
SIGNAL 1 28
CHAIN 29 427 Tumor necrosis factor receptor superfamily member 16.
REPEAT 31 64 TNFR-Cys 1.
REPEAT 66 107 TNFR-Cys 2.
REPEAT 108 146 TNFR-Cys 3.
REPEAT 148 188 TNFR-Cys 4.
DOMAIN 344 421 Death.
REGION 326 341 Mediates interaction with KIDINS220 (By similarity).
DISULFID 32 43 By similarity.
DISULFID 44 57 By similarity.
DISULFID 47 64 By similarity.
DISULFID 67 83 By similarity.
DISULFID 86 99 By similarity.
DISULFID 89 107 By similarity.
DISULFID 109 122 By similarity.
DISULFID 125 138 By similarity.
DISULFID 128 146 By similarity.
DISULFID 149 164 By similarity.
DISULFID 167 180 By similarity.
DISULFID 170 188 By similarity.
Amino Acid Sequence for TNR16_HUMAN » Tumor necrosis factor receptor superfamily member 16
MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG EGVAQPCGAN QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV EADDAVCRCA YGYYQDETTG RCEACRVCEA GSGLVFSCQD KQNTVCEECP DGTYSDEANH VDPCLPCTVC EDTERQLREC TRWADAECEE IPGRWITRST PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ PVVTRGTTDN LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL LNGSAGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA LLAALRRIQR ADLVESLCSE STATSPV