TNR14_HUMAN » Tumor necrosis factor receptor superfamily member 14

TNR14_HUMAN » Tumor necrosis factor receptor superfamily member 14
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Topology in Plasma membrane
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TNR14_HUMAN » Tumor necrosis factor receptor superfamily member 14 » Herpes virus entry mediator A;Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2;TR2;
Hydrophobic Thickness 36.0 ± 4.0 Å
Tilt Angle 20 ± 6°
ΔGtransfer -26.3 kcal/mol
ΔGfold -16.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 201-226 (197-229)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Herpes simplex infection (KEGG)

Immune System (Reactome)

PDB 4fhq (39-162), 2aw2 (B/Y=39-142), 1jma (B=39-199), 4rsu (D/E...=39-162)
OPM none
Complexes

BTLA:TNR14_HUMAN

TNF14:TNR14_HUMAN

Interactions

A4, Complex: A4:TNR14, PubMed

BTLA, Complex: BTLA:TNR14, PDBID: 2aw2, PubMed

ESR1, Complex: TNR14:ESR1, PubMed

HTRA2, Complex: HTRA2:TNR14, PubMed

MBTP1, Complex: TNR14:MBTP1, PubMed

NCLN, Complex: TNR14:NCLN, PubMed

SC11A, Complex: SC11A:TNR14, PubMed

SRPRB, Complex: SRPRB:TNR14, PubMed

SSRD, Complex: TNR14:SSRD, PubMed

TIP, Complex: TNR14:TIP, PubMed

TNF14, Complex: TNR14:TNF14, PDBID: 4rsu, PubMed

UD11, Complex: TNR14:UD11, PubMed

Domains

AA: 78-119, PDBID: 1JMA, Subunit B, Seq Identity:100%, TNFR/NGFR cysteine-rich region

UniProt annotation for TNR14_HUMAN » Tumor necrosis factor receptor superfamily member 14
FUNCTION: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses.

TISSUE SPECIFICITY: Widely expressed, with the highest expression in lung, spleen and thymus.

UniProt features for TNR14_HUMAN » Tumor necrosis factor receptor superfamily member 14
SIGNAL 1 38
CHAIN 39 283 Tumor necrosis factor receptor superfamily member 14.
REPEAT 42 75 TNFR-Cys 1.
REPEAT 78 119 TNFR-Cys 2.
REPEAT 121 162 TNFR-Cys 3.
DISULFID 42 53
DISULFID 54 67
DISULFID 57 75
DISULFID 78 93
DISULFID 96 111
DISULFID 99 119
DISULFID 121 138
DISULFID 127 135
Amino Acid Sequence for TNR14_HUMAN » Tumor necrosis factor receptor superfamily member 14
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH