TNR12_HUMAN » Tumor necrosis factor receptor superfamily member 12A

TNR12_HUMAN » Tumor necrosis factor receptor superfamily member 12A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNR12_HUMAN » Tumor necrosis factor receptor superfamily member 12A » Fibroblast growth factor-inducible immediate-early response protein 14;FGF-inducible 14; Tweak-receptor;TweakR;
Hydrophobic Thickness 36.0 ± 5.0 Å
Tilt Angle 13 ± 2°
ΔGtransfer -20.9 kcal/mol
ΔGfold -13.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 78-102 (78-108)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 2eqp (28-70), 2rpj (28-70), 2kmz (28-80)
OPM 2kmz
Complexes none
Interactions

PVRL2, Complex: PVRL2:TNR12

PVR, Complex: PVR:TNR12

TNF12, Complex: TNR12:TNF12, PubMed

Domains

AA: 1-129, PDBID: 2EQP, Subunit A, Seq Identity:100%, Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain

UniProt annotation for TNR12_HUMAN » Tumor necrosis factor receptor superfamily member 12A
FUNCTION: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

SUBUNIT: Associates with TRAF1 and TRAF2, and probably also with TRAF3.

TISSUE SPECIFICITY: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

INDUCTION: By FGF1 and phorbol ester.

UniProt features for TNR12_HUMAN » Tumor necrosis factor receptor superfamily member 12A
SIGNAL 1 27 Potential.
CHAIN 28 129 Tumor necrosis factor receptor superfamily member 12A.
REPEAT 36 67 TNFR-Cys; atypical.
DISULFID 36 49
DISULFID 52 67
DISULFID 55 64
Amino Acid Sequence for TNR12_HUMAN » Tumor necrosis factor receptor superfamily member 12A
MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE GCPAVALIQ