TNFL9_HUMAN » Tumor necrosis factor ligand superfamily member 9

TNFL9_HUMAN » Tumor necrosis factor ligand superfamily member 9
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNFL9_HUMAN » Tumor necrosis factor ligand superfamily member 9 » 4-1BB ligand;4-1BBL;
Hydrophobic Thickness 35.6 ± 3.2 Å
Tilt Angle 41 ± 0°
ΔGtransfer -34.6 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 26-55 (26-61)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 2x29 (A=80-246)
OPM none
Complexes none
Interactions

TLR4, Complex: TNFL9:TLR4

TNR9, Complex: TNFL9:TNR9, PubMed

Domains

AA: 107-240, PDBID: 2X29, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNFL9_HUMAN » Tumor necrosis factor ligand superfamily member 9
FUNCTION: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Expressed in brain, placenta, lung, skeletal muscle and kidney.

UniProt features for TNFL9_HUMAN » Tumor necrosis factor ligand superfamily member 9
CHAIN 1 254 Tumor necrosis factor ligand superfamily member 9.
Amino Acid Sequence for TNFL9_HUMAN » Tumor necrosis factor ligand superfamily member 9
MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA CPWAVSGARA SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS PRSE