TNFL8_HUMAN » Tumor necrosis factor ligand superfamily member 8

TNFL8_HUMAN » Tumor necrosis factor ligand superfamily member 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNFL8_HUMAN » Tumor necrosis factor ligand superfamily member 8 » CD30 ligand;CD30-L;
Hydrophobic Thickness 34.4 ± 3.0 Å
Tilt Angle 31 ± 1°
ΔGtransfer -32.5 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 38-65 (33-65)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

TNR8, Complex: TNR8:TNFL8, PubMed

Domains

AA: 113-230, PDBID: 1A8M, Subunit A, Seq Identity:21%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNFL8_HUMAN » Tumor necrosis factor ligand superfamily member 8
FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

SUBUNIT: Homotrimer.

UniProt features for TNFL8_HUMAN » Tumor necrosis factor ligand superfamily member 8
CHAIN 1 234 Tumor necrosis factor ligand superfamily member 8.
DISULFID 151 177 Potential.
Amino Acid Sequence for TNFL8_HUMAN » Tumor necrosis factor ligand superfamily member 8
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD