TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6

TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6
Magnify TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6 » Apoptosis antigen ligand;APTL; CD95 ligand;CD95-L; Fas antigen ligand;Fas ligand; FasL;
Hydrophobic Thickness 34.4 ± 4.8 Å
Tilt Angle 27 ± 2°
ΔGtransfer -31.3 kcal/mol
ΔGfold -24.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 80-105 (77-114)
Pathways

African trypanosomiasis (KEGG)

Allograft rejection (KEGG)

Apoptosis (Reactome)

Apoptosis (KEGG)

Autoimmune thyroid disease (KEGG)

Chagas disease (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Graft-versus-host disease (KEGG)

Hepatitis B (KEGG)

Herpes simplex infection (KEGG)

Influenza A (KEGG)

MAPK signaling pathway (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Neurotrophin signaling pathway (KEGG)

Pathways in cancer (KEGG)

PI3K-Akt signaling pathway (KEGG)

Proteoglycans in cancer (KEGG)

Type I diabetes mellitus (KEGG)

PDB 4msv (A=130-281)
OPM none
Complexes none
Interactions

DHB7, Complex: DHB7:TNFL6, PubMed

TNR1A, Complex: TNFL6:TNR1A, PubMed

TNR6, Complex: TNFL6:TNR6, PDBID: 1bzi

TR10B, Complex: TNFL6:TR10B, PubMed

Domains

AA: 160-281, PDBID: 4MSV, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6
FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

FUNCTION: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.

SUBUNIT: Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.

DISEASE: Autoimmune lymphoproliferative syndrome 1B (ALPS1B) OMIM: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6
CHAIN 1 281 Tumor necrosis factor ligand superfamily member 6, membrane form.
CHAIN 1 129 ADAM10-processed FasL form.
CHAIN 1 81 FasL intracellular domain.
CHAIN 130 281 Tumor necrosis factor ligand superfamily member 6, soluble form.
SITE 81 82 Cleavage; by SPPL2A (Probable).
SITE 129 130 Cleavage; by ADAM10 (Probable).
DISULFID 202 233 Potential.
Amino Acid Sequence for TNFL6_HUMAN » Tumor necrosis factor ligand superfamily member 6
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L