TNFL4_HUMAN » Tumor necrosis factor ligand superfamily member 4

TNFL4_HUMAN » Tumor necrosis factor ligand superfamily member 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNFL4_HUMAN » Tumor necrosis factor ligand superfamily member 4 » Glycoprotein Gp34;OX40 ligand;OX40L; TAX transcriptionally-activated glycoprotein 1;
Hydrophobic Thickness 26.0 ± 5.2 Å
Tilt Angle 54 ± 0°
ΔGtransfer -22.2 kcal/mol
ΔGfold -12.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 22-48 (18-55)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 2hev (F=51-183)
OPM 2hew (MOUSE)
Complexes

TNFL4:TNR4_MOUSE

Interactions

TNR4, Complex: TNFL4:TNR4, PDBID: 2hev, PubMed

Domains

AA: 76-182, PDBID: 2hev, Subunit F, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNFL4_HUMAN » Tumor necrosis factor ligand superfamily member 4
FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

SUBUNIT: Homotrimer.

INDUCTION: By HTLV-1 transactivator p40-Tax.

DISEASE: Systemic lupus erythematosus (SLE) OMIM: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

UniProt features for TNFL4_HUMAN » Tumor necrosis factor ligand superfamily member 4
CHAIN 1 183 Tumor necrosis factor ligand superfamily member 4.
DISULFID 97 181
Amino Acid Sequence for TNFL4_HUMAN » Tumor necrosis factor ligand superfamily member 4
MERVQPLEEN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL