TNFC_HUMAN » Lymphotoxin-beta

TNFC_HUMAN » Lymphotoxin-beta
Magnify TNFC_HUMAN » Lymphotoxin-betaEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNFC_HUMAN » Lymphotoxin-beta » LT-beta; Tumor necrosis factor C;TNF-C; Tumor necrosis factor ligand superfamily member 3;
Hydrophobic Thickness 34.8 ± 4.8 Å
Tilt Angle 32 ± 1°
ΔGtransfer -22.7 kcal/mol
ΔGfold -20.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 19-47 (18-47)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

NF-kappa B signaling pathway (KEGG)

Rheumatoid arthritis (KEGG)

PDB 4mxw (B/D/Y/Z=86-244)
OPM none
Complexes

TNFB:TNR3:TNFC_HUMAN

Interactions

TNF14, Complex: TNFC:TNF14, PubMed

TNR1A, Complex: TNFC:TNR1A, PubMed

TNR3, Complex: TNFB:TNR3:TNFC, PDBID: 4mxw, PubMed

Domains

AA: 102-243, PDBID: 4MXW, Subunit B, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNFC_HUMAN » Lymphotoxin-beta
FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.

TISSUE SPECIFICITY: Spleen and thymus.

UniProt features for TNFC_HUMAN » Lymphotoxin-beta
CHAIN 1 244 Lymphotoxin-beta.
Amino Acid Sequence for TNFC_HUMAN » Lymphotoxin-beta
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA VMVG