TNF18_HUMAN » Tumor necrosis factor ligand superfamily member 18

TNF18_HUMAN » Tumor necrosis factor ligand superfamily member 18
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNF18_HUMAN » Tumor necrosis factor ligand superfamily member 18 » Activation-inducible TNF-related ligand;AITRL; Glucocorticoid-induced TNF-related ligand;hGITRL;
Hydrophobic Thickness 40.8 ± 2.0 Å
Tilt Angle 0 ± 5°
ΔGtransfer -30.9 kcal/mol
ΔGfold -24.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 46-74 (44-77)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 3b94 (A/B/C/D=72-199), 3b93 (A/B/C=72-199), 2q1m (A=74-199), 2r30 (A=74-199), 2r32 (A=74-199)
OPM none
Complexes

TNF18:TNF18_HUMAN

Interactions

TNF18, Complex: Homotrimer of tumor necrosis factor 18, PDBID: 3B93

TNR18, Complex: TNR18:TNF18, PubMed

Domains

AA: 89-192, PDBID: 2q1m, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNF18_HUMAN » Tumor necrosis factor ligand superfamily member 18
FUNCTION: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed). Promotes leukocyte adhesion to endothelial cells (PubMed). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

SUBUNIT: Homodimer (By similarity). Homotrimer.

TISSUE SPECIFICITY: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

INDUCTION: Up-regulated after stimulation by bacterial lipopolysaccharides (LPS).

UniProt features for TNF18_HUMAN » Tumor necrosis factor ligand superfamily member 18
CHAIN 1 199 Tumor necrosis factor ligand superfamily member 18.
DISULFID 80 100
Amino Acid Sequence for TNF18_HUMAN » Tumor necrosis factor ligand superfamily member 18
MTLHPSPITC EFLFSTALIS PKMCLSHLEN MPLSHSRTQG AQRSSWKLWL FCSIVMLLFL CSFSWLIFIF LQLETAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY GQVAPNANYN DVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV LKNNTYWGII LLANPQFIS