TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15

TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15
Magnify TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15 » TNF ligand-related molecule 1;Vascular endothelial cell growth inhibitor;
Hydrophobic Thickness 34.4 ± 3.6 Å
Tilt Angle 16 ± 11°
ΔGtransfer -23.8 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 35-59 (31-61)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 2o0o (A/B/C=72-251), 2re9 (A/B/C=72-251), 2qe3 (A=72-251), 2rjk (A=72-251), 2rjl (A=72-251), 3k51 (A=72-251), 3mi8 (A=72-251)
OPM none
Complexes

TNF15:TNF15_HUMAN

Interactions

TNF15, Complex: Homotrimer of tumor necrosis factor 15, PDBID: 2O0O

TNR25, Complex: TNR25:TNF15, PubMed

Domains

AA: 117-251, PDBID: 2O0O, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15
FUNCTION: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

INDUCTION: Up-regulated by IL1A/interleukin-1 alpha and TNF.

UniProt features for TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15
CHAIN 1 251 Tumor necrosis factor ligand superfamily member 15, membrane form.
CHAIN 72 251 Tumor necrosis factor ligand superfamily member 15, secreted form.
SITE 71 72 Cleavage.
SITE 187 187 Important for binding TNFRSF6B.
SITE 190 190 Important for binding TNFRSF6B.
DISULFID 162 202
Amino Acid Sequence for TNF15_HUMAN » Tumor necrosis factor ligand superfamily member 15
MAEDLGLSFG ETASVEMLPE HGSCRPKARS SSARWALTCC LVLLPFLAGL TTYLLVSQLR AQGEACVQFQ ALKGQEFAPS HQQVYAPLRA DGDKPRAHLT VVRQTPTQHF KNQFPALHWE HELGLAFTKN RMNYTNKFLL IPESGDYFIY SQVTFRGMTS ECSEIRQAGR PNKPDSITVV ITKVTDSYPE PTQLLMGTKS VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK EDKTFFGAFL L