TNF14_HUMAN » Tumor necrosis factor ligand superfamily member 14

TNF14_HUMAN » Tumor necrosis factor ligand superfamily member 14
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNF14_HUMAN » Tumor necrosis factor ligand superfamily member 14 » Herpes virus entry mediator ligand;HVEM-L; Herpesvirus entry mediator ligand;
Hydrophobic Thickness 34.0 ± 1.6 Å
Tilt Angle 2 ± 1°
ΔGtransfer -39.5 kcal/mol
ΔGfold -12.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 36-59 (33-61)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Herpes simplex infection (KEGG)

NF-kappa B signaling pathway (KEGG)

PDB 4rsu (A/B...=83-240), 4en0 (A/B/C=83-240), 4kg8 (A/B/C=83-240), 4j6g (A/B=83-240), 4kgg (A/B=83-240), 4kgq (A/B=83-240)
OPM none
Complexes

TNF14:TNR14_HUMAN

TNF14:TNF14_HUMAN

Interactions

A4, Complex: TNF14:A4, PubMed

TNF14, Complex: Homotrimer of tumor necrosis factor 14, PDBID: 4EN0

TNFC, Complex: TNFC:TNF14, PubMed

TNR14, Complex: TNR14:TNF14, PDBID: 4rsu, PubMed

TNR3, Complex: TRAF3:TNR3:DBLOH:TRAF2:BIRC2:TNF14, PubMed

Domains

AA: 112-240, PDBID: 4EN0, Subunit C, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNF14_HUMAN » Tumor necrosis factor ligand superfamily member 14
FUNCTION: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

INDUCTION: Up-regulated after T-cell activation.

UniProt features for TNF14_HUMAN » Tumor necrosis factor ligand superfamily member 14
CHAIN 1 240 Tumor necrosis factor ligand superfamily member 14, membrane form.
CHAIN ?83 240 Tumor necrosis factor ligand superfamily member 14, soluble form.
SITE 82 83 Cleavage (Potential).
DISULFID 154 187
Amino Acid Sequence for TNF14_HUMAN » Tumor necrosis factor ligand superfamily member 14
MEESVVRPSV FVVDGQTDIP FTRLGRSHRR QSCSVARVGL GLLLLLMGAG LAVQGWFLLQ LHWRLGEMVT RLPDGPAGSW EQLIQERRSH EVNPAAHLTG ANSSLTGSGG PLLWETQLGL AFLRGLSYHD GALVVTKAGY YYIYSKVQLG GVGCPLGLAS TITHGLYKRT PRYPEELELL VSQQSPCGRA TSSSRVWWDS SFLGGVVHLE AGEEVVVRVL DERLVRLRDG TRSYFGAFMV