TNF12_HUMAN » Tumor necrosis factor ligand superfamily member 12

TNF12_HUMAN » Tumor necrosis factor ligand superfamily member 12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNF12_HUMAN » Tumor necrosis factor ligand superfamily member 12 » APO3 ligand;TNF-related weak inducer of apoptosis;TWEAK;
Hydrophobic Thickness 38.8 ± 4.4 Å
Tilt Angle 1 ± 5°
ΔGtransfer -25.7 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 18-44 (18-48)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 4ht1 (T=97-249)
OPM none
Complexes none
Interactions

C163A, Complex: C163A:TNF12, PubMed

TN13B, Complex: TN13B:TNF12

TNR12, Complex: TNR12:TNF12, PubMed

TNR25, Complex: TNF12:TNR25, PubMed

Domains

AA: 131-248, PDBID: 4HT1, Subunit T, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNF12_HUMAN » Tumor necrosis factor ligand superfamily member 12
FUNCTION: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

SUBUNIT: Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.

TISSUE SPECIFICITY: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.

UniProt features for TNF12_HUMAN » Tumor necrosis factor ligand superfamily member 12
CHAIN 1 249 Tumor necrosis factor ligand superfamily member 12, membrane form.
CHAIN 94 249 Tumor necrosis factor ligand superfamily member 12, secreted form.
SITE 93 94 Cleavage.
Amino Acid Sequence for TNF12_HUMAN » Tumor necrosis factor ligand superfamily member 12
MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL TYFGLFQVH