TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11

TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11
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Topology in Plasma membrane
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TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11 » Osteoclast differentiation factor;ODF; Osteoprotegerin ligand;OPGL; Receptor activator of nuclear factor kappa-B ligand;RANKL; TNF-related activation-induced cytokine;TRANCE;
Hydrophobic Thickness 34.8 ± 0.7 Å
Tilt Angle 2 ± 6°
ΔGtransfer -19.4 kcal/mol
ΔGfold -13.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 48-70 (43-73)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

NF-kappa B signaling pathway (KEGG)

Osteoclast differentiation (KEGG)

Rheumatoid arthritis (KEGG)

PDB 3urf (A=162-317)
OPM none
Complexes

TNF11:TNR11_MOUSE

TNF11:TNF11_MOUSE

Interactions

ADA17, Complex: ADA17:TNF11, PubMed

ADA19, Complex: TNF11:ADA19, PubMed

MBTP1, Complex: TNF11:MBTP1, PubMed

TNF11, Complex: Homotrimer of tumor necrosis factor 11, PDBID: 1S55

TNR11, Complex: TNF11:TNR11, PDBID: 3me2, PubMed

Domains

AA: 185-313, PDBID: 3URF, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11
FUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

SUBUNIT: Homotrimer (Probable). Interacts with TNFRSF11B.

TISSUE SPECIFICITY: Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

INDUCTION: Up-regulated by T-cell receptor stimulation.

DISEASE: Osteopetrosis, autosomal recessive 2 (OPTB2) OMIM: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. disease is caused by mutations affecting the gene represented in this entry.

UniProt features for TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11
CHAIN 1 317 Tumor necrosis factor ligand superfamily member 11, membrane form.
CHAIN 140 317 Tumor necrosis factor ligand superfamily member 11, soluble form (By similarity).
SITE 139 140 Cleavage (By similarity).
Amino Acid Sequence for TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11
MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPPAPHQ PPAASRSMFV ALLGLGLGQV VCSVALFFYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDTK LIPDSCRRIK QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD PDQDATYFGA FKVRDID