|TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11 » Osteoclast differentiation factor;ODF; Osteoprotegerin ligand;OPGL; Receptor activator of nuclear factor kappa-B ligand;RANKL; TNF-related activation-induced cytokine;TRANCE;|
|Hydrophobic Thickness||34.8 ± 0.7 Å|
|Tilt Angle||2 ± 6°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB|
|TM Segments||48-70 (43-73)|
NF-kappa B signaling pathway (KEGG)
Osteoclast differentiation (KEGG)
Rheumatoid arthritis (KEGG)
|UniProt annotation for TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11|
|FUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. SUBUNIT: Homotrimer (Probable). Interacts with TNFRSF11B. TISSUE SPECIFICITY: Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. INDUCTION: Up-regulated by T-cell receptor stimulation. DISEASE: Osteopetrosis, autosomal recessive 2 (OPTB2) OMIM: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. disease is caused by mutations affecting the gene represented in this entry.|
|UniProt features for TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11|
CHAIN 1 317 Tumor necrosis factor ligand superfamily member 11, membrane form. |
CHAIN 140 317 Tumor necrosis factor ligand superfamily member 11, soluble form (By similarity).
SITE 139 140 Cleavage (By similarity).
|Amino Acid Sequence for TNF11_HUMAN » Tumor necrosis factor ligand superfamily member 11|
|MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPPAPHQ PPAASRSMFV ALLGLGLGQV VCSVALFFYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDTK LIPDSCRRIK QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD PDQDATYFGA FKVRDID|